原发性骨淋巴瘤的诊疗进展

Progress in diagnosis and treatment of primary lymphoma of bone

原发性骨淋巴瘤(PLB)是一类少见的结外淋巴瘤,占骨恶性肿瘤的3%~7%,占结外淋巴瘤约5%,占成年人所有淋巴瘤的2%。PLB可发生于任何年龄阶段,但好发于中老年人,平均发病年龄为45~60岁,男性略多于女性。PLB通常以病变部位疼痛或局部软组织肿胀起病,影像学表现无特异性,诊断必须通过手术取样行病理活组织检查来确诊。目前PLB以全身化疗联合受累骨放疗为主。文章对PLB的诊疗现状及进展进行综述。

Primary lymphoma of bone(PLB)is a rare extra nodal lymphoma,which accounts for 3%-7%of malignant bone tumors,about 5%of extra nodal lymphomas,and 2%of lymphomas in adults.PLB can occur in any age group,but it is more commonly found in middle-aged and elderly people with the average age of onset of 45-60 years old,and it is slightly more common in males than in females.The patients with PLB usually present with pain or swelling of local soft tissue,and the radiological feature is atypical.It must be diagnosed by pathological biopsy.At present,PLB is mainly treated by systemic chemotherapy combined with radiotherapy of the affected bone.This article will review the current progress in the diagnosis and treatment of PLB.