白虎加人参汤联合复方薤白胶囊治疗重症肺部感染疗效研究

Clinical research on Baihu Renshen decoction combined with compound Xiebai capsule in treatment of severe pulmonary infection

目的:探讨白虎加人参汤联合复方薤白胶囊治疗重症肺部感染疗效及对血清可溶性髓样细胞触发性受体-1(sTREM-1)、肺表面活性蛋白D(SP-D)的影响。方法:选择重症肺部感染患者103例,随机分为对照组、观察组。对照组采用常规西医加复方薤白胶囊治疗,观察组在对照组基础上加用白虎加人参汤。治疗后,比较两组临床疗效、中医证候积分、血清sTREM-1和SP-D水平变化,使用临床肺部感染评分(CPIS)、急性生理和慢性健康状况Ⅱ(APACHEⅡ)评分评价肺部感染、健康状况。结果:治疗后,观察组总有效率94.23%高于对照组的80.39%(P<0.05)。治疗后,观察组各中医证候积分低于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组sTREM-1、SP-D水平低于对照组,差异有统计学意义(均P<0.05)。治疗后,观察组CPIS评分、APACHEⅡ评分低于对照组,差异有统计学意义(均P<0.05)。结论:白虎加人参汤联合复方薤白胶囊治疗重症肺部感染临床疗效较好,可改善患者症状,减轻肺部感染程度。

Objective:To evaluate clinical efficacy of Baihu Renshen decoction combined with compound Xiebai capsule in treatment of severe pulmonary infection and its influence on levels of soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and pulmonary surfactant protein D(SP-D)of patients.Methods:103 patients with severe pulmonary infection were randomly divided into control group and observation group.The control group were treated with conventional western medicine and compound Xiebai capsule,and the observation group were additionally given Baihu Renshen decoction on the basis of the control group.After treatment,clinical efficacy,scores of TCM syndromes and levels of serum sTREM-1 and SP-D were compared between the two groups.Clinical pulmonary infection score(CPIS),acute physiology and chronic health evaluationⅡ(APACHEⅡ)were applied to evaluate the pulmonary infection and health status of the two groups.Results:After treatment,the effective rate of clinical treatment in the observation group was 94.23%was higher than 80.39%in the control group.After treatment,the scores of TCM syndromes of the observation group were lower than those in the control group(all P<0.05).After treatment,the levels of serum sTREM-1 and SP-D were lower in the observation group than those in the control group(all P<0.05).After treatment,the scores of CPIS and APACHEⅡof the observation group were lower than those of the control group(all P<0.05).Conclusion:Baihu Renshen decoction combined with compound Xiebai capsule has obvious clinical efficacy in the treatment of severe pulmonary infection,improve syndromes,reduce degree of pulmonary infection.