血浆脂蛋白a浓度与新疆地区青年发生急性缺血性脑卒中的关联性研究

Study on the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang

目的探讨血浆脂蛋白a浓度与新疆地区青年急性缺血性脑卒中的关联性。方法选取2016年7月至2020年12月在新疆医科大学第一附属医院神经内科中心住院的青年急性缺血性脑卒中患者316例作为青年卒中组,随机选取同期住院青年非卒中患者637例作为青年非卒中组。收集所有研究对象的病史和临床资料,分析血浆脂蛋白a浓度与青年发生急性缺血性脑卒中之间的关联性。结果青年卒中组的血浆脂蛋白a浓度[140.55(208.88)]明显高于青年非卒中组的血浆脂蛋白a浓度[95.00(151.38)]。按照族别分别比较青年卒中组与青年非卒中组的血浆脂蛋白a浓度,不论是汉族、维吾尔族还是哈萨克族,均显示青年卒中组的血浆脂蛋白a浓度高于青年非卒中组(P<0.05)。多因素logistic回归分析表明脂蛋白a可能是新疆地区青年发生急性缺血性脑卒中的独立危险因素之一(OR=1.601,95%CI 1.342~1.910,P<0.05)。进一步探究汉族、维吾尔族、哈萨克族青年的血浆脂蛋白a浓度与发生急性缺血性脑卒中之间的关联性。显示在汉族青年中脂蛋白a水平升高与青年发生急性缺血性脑卒中明显相关1.751(95%CI 1.404~2.183,P<0.05);随着血浆脂蛋白a浓度的升高,急性缺血性脑卒中的发生风险也进一步增加,最高四分位数水平的研究人群相对于最低四分位数水平的研究人群,风险比为4.948(95%CI 2.528~9.686,P<0.05)。但是在维吾尔族与哈萨克族中,并未显示出脂蛋白a浓度与青年发生急性缺血性脑卒中的关联性。结论血浆脂蛋白a浓度与新疆地区青年发生急性缺血性脑卒中具有关联性。进一步探究关联性的民族差异,发现血浆脂蛋白a浓度与汉族青年发生急性缺血性脑卒中密切相关,在维吾尔族与哈萨克族青年中未显示出关联性。

Objective To investigate the relationship between plasma lipoprotein a concentration and acute ischemic stroke in young people in Xinjiang.Methods 316 young acute ischemic stroke patients who were hospitalized in the Neurology Center of the First Affiliated Hospital of Xinjiang Medical University from July 2016 to December 2020 were selected as the young stroke group,and 637 young non-stroke patients hospitalized during the same period were randomly selected As a youth non-stroke group.The medical history and clinical data of all subjects were collected,and the relationship between plasma lipoprotein a concentration and the occurrence of acute ischemic stroke in young people was analyzed.Results The plasma lipoprotein a concentration in the youth stroke group[140.55(208.88)]was significantly higher than that in the youth non-stroke group[95.00(151.38)].Comparing the plasma lipoprotein a concentration of the young stroke group and the young non-stroke group according to ethnicity,whether it is Han,Uygur or Kazakh,the plasma lipoprotein a concentration of the young stroke group is higher than that of the young non-stroke group(P<0.05).Multivariate logistic regression analysis indicated that lipoprotein a may be one of the independent risk factors for acute ischemic stroke in young people in Xinjiang(OR=1.601,95%CI 1.342~1.910,P<0.05).Further explore the relationship between the concentration of plasma lipoprotein a and the occurrence of acute ischemic stroke in Han,Uygur,and Kazakh youths.It shows that the increase of lipoprotein a level in Han youth is significantly related to the occurrence of acute ischemic stroke in young people.1.751(95%CI 1.404~2.183,P<0.05);with the increase of plasma lipoprotein a concentration,acute deficiency The risk of bloody stroke also further increased.The risk ratio of the study population at the highest quartile level to the study population at the lowest quartile level was 4.948(95%CI 2.528~9.686,P<0.05).However,in the Uygur and Kazakhs,there is no correlation between the concentration of lipoprotein a and the occurrence of acute ischemic stroke in young people.Conclusion The concentration of plasma lipoprotein a is associated with the occurrence of acute ischemic stroke in young people in Xinjiang.Further exploring the ethnic differences in the correlation,it is found that the plasma lipoprotein a concentration is closely related to the occurrence of acute ischemic stroke in the Han youth,and there is no correlation between the Uyghur and Kazakh youths.