冠心病痰瘀互结证易患因素及其相关生物学指标特征述评

A Review of Susceptible Factors and Related Biological Indexes of Phlegm and Blood Stasis Syndrome of Coronary Heart Disease

本文对冠心病痰瘀互结证易患因素及其生物学指标进行述评,从易患因素、血液生化指标、影像学指标、组学研究等方面对目前较为广泛报道的指标进行归类,根据痰瘀互结证发生发展过程分析上述指标的变化规律,初步梳理其研究状况及不足,并探讨未来的研究思路和方向。认为冠心病痰瘀互结证存在各项生物学指标异常广泛加重的特征,因此探索多维指标联合辅助诊断痰瘀互结证的影响意义深远。虽然目前冠心病痰瘀互结证相关生物学指标研究已取得较多成果,但研究方法学上仍存在一定问题,需要进一步在诊断标准规范化,对照组设置合理性,证据质量和级别提升等方面进行方法学优化。

This paper reviews the susceptible factors and biological indexes of phlegm and blood stasis syndrome of coronary heart disease,the widely reported indicators were classified into susceptible factors,blood biochemical indicators,imaging indicators,gene and polymorphism.According to the occurrence and development process of the syndrome of phlegm and blood stasis,we analyzed the changes of the above indicators,initially sorted out the research status and deficiencies,and discussed future research ideas and directions.It is believed that the syndrome of phlegm and blood stasis syndrome in coronary heart disease has the characteristics of various biological indicators that are abnormal and extensive.Therefore,it is of far-reaching significance to explore the combined diagnosis of phlegm and blood stasis syndrome by multi-dimensional indicators.It is pointed out that although many results have been achieved in the research on the biological indicators related to the syndrome of phlegm and blood stasis in coronary heart disease,there are still some problems in the research methodology.It is necessary to further standardize the diagnostic criteria,set the reasonableness of the control group,and improve the quality and level of evidence by methodological optimization.