米非司酮配伍米索前列醇应用于Ⅰ、Ⅱ型子宫瘢痕妊娠的价值

Value of mifepristone combined with misoprostol in typeⅠandⅡuterine scar pregnancy

目的:探讨米非司酮配伍米索前列醇应用于Ⅰ、Ⅱ型子宫瘢痕妊娠(CSP)的价值。方法:2020年1月-2020年8月收治Ⅰ型、Ⅱ型CSP(孕周<8周)患者60例,随机分为两组。对照组在介入栓塞后给予B超引导下清宫;试验组给予米非司酮配伍米索前列醇治疗后再行清宫术。比较两组治疗安全性和有效性。结果:试验组住院费用、住院时间和月经恢复时间均低于对照组,但术后出血量高于对照组,差异均有统计学意义(P<0.05);两组血β-HCG转阴时间比较,差异无统计学意义(P>0.05)。试验组术后并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:米非司酮配伍米索前列醇应用于Ⅰ型及Ⅱ型CSP患者中,可以有效保障患者的治疗安全性和有效性,减少治疗费用,是一种安全、简便且可广泛推广的新方法。

Objective:To explore the value of mifepristone combined with misoprostol in type Ⅰ and Ⅱ uterine scar pregnancy.Methods:From January 2020 to August 2020,60 patients with type Ⅰ and type Ⅱ CSP(gestational week<8 weeks)were selected.They were randomly divided into two groups.The control group was given uterine clearance under the guidance of B-ultrasound after intervention.The experimental group underwent uterine curettage after mifepristone combined with misoprostol.We compared the safety and efficacy of the two groups.Results:In the experimental group,the hospitalization cost,hospitalization time and menstrual recovery time were lower than those in the control group,but the amount of postoperative bleeding was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in blood β-HCG turning negative time between the two groups(P>0.05).In the experimental group,the incidence of postoperative complications was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Mifepristone combined with misoprostol can effectively ensure the safety and effectiveness of treatment in patients with typeⅠand typeⅡCSP,can reduce the treatment cost of patients.It is a safe,simple and widely popularized new method.