某院387例患者亚胺培南-西司他丁钠临床使用的相关指标及其不合理用药的原因分析

Analysis of Related Indicators of Imipenem-cilastatin’s Clinical Medication in 387 Cases in a Hospital and Its Reasons for Irrational Drug Usage

目的:分析医院亚胺培南-西司他丁钠临床使用的合理性及不合理的原因。方法:抽取2019年10月—12月医院临床使用注射用亚胺培南-西司他丁钠治疗患者387例病历资料,分析其亚胺培南-西司他丁钠临床使用的相关指标的合理性及不合理的原因。结果:387例临床使用注射用亚胺培南-西司他丁钠治疗患者中,其中用药不适宜59例(占15.24%);使用量TOP 6的科室中使用亚胺培南-西司他丁钠患者256例(占66.15%),用药前送检标本微生物送检率为29.46%,治疗后送检率为51.94%;抗菌药物联合用药以二联用药的方式为主;用药期间产生不良反应75例(占19.38%,以皮疹和瘙痒为主)。结论:医院临床注射用亚胺培南-西司他丁钠的使用尚存在不合理现象,医院行政部门应加强对合理用药的教育与管理,以促进临床合理用药。

Objective:To analyze the rationality and unreasonable reasons of clinical medication of imipenemcilastatin sodium in a hospital.Methods:The medical records of 387 patients treated with imipenem/cisastatin for injection from October to December 2019 in the hospital were selected to analyze the rationality and unreasonable reasons of the relevant indicators of the clinical medication of imipenem/cisastatin.Results:Among 387 cases of patients treated with imipenem/cisastatin for injection,59 cases(15.24%)were unsuitable.In the TOP 6 departments with the use of imipenem/cisastatin,256 patients received imipenem/cisastatin,accounting for 66.15%.The microbial test rate was 29.46%before treatment and 51.94%after treatment.The combined medication of antibacterials was mainly in the form of 2 kinds of drug combinations.75 cases(19.38%)had adverse drug reactions(mainly rash and pruritus).Conclusions:The usage of imipenem/cisastatin for injection in hospital still exists unreasonable phenomenon,the administrative department of hospital should strengthen the education and management of rational drug use knowledge to promote rational drug use in clinic.