托吡酯致双眼脉络膜脱离

Bilateral choroidal detachment induced by topiramate

1例57岁男性癫痫患者因服用丙戊酸钠疗效不佳,加用托吡酯25 mg口服、1次/晚。7 d后,患者出现视力下降伴眼部疼痛肿胀,眼部超声检查示双眼脉络膜脱离。考虑与托吡酯有关,停用该药并给予醋酸泼尼松60 mg口服、1次/d治疗。8 d后,患者眼部疼痛、肿胀明显好转,眼部超声检查示脉络膜脱离表现消失。停药15 d后患者眼部症状消失。

A 57‑year‑old male patient with epilepsy was additionally given topiramate 25 mg orally once at night because of poor curative effect of sodium valproate.Seven days later,the patient developed vision loss with eye pain and swelling.Ocular ultrasonography showed bilateral choroidal detachment,which was considered to be related to topiramate.Topiramate was discontinued and prednisone acetate 60 mg once daily was given,and 8 days later,the patient′s eye pain and swelling were improved.Ocular ultrasonography showed that choroidal detachment disappeared.Fifteen days after drug withdrawal,his ocular symptoms disappeared.