嘌呤受体参与调控神经病理性疼痛机制的研究进展

Effect of purinergic receptors in neuropathic pain

神经病理性疼痛是损伤或疾病影响躯体感觉神经系统所致的疼痛。目前针对神经病理性疼痛的药物治疗效果不佳,这与当前神经病理性疼痛的发生机制尚不明确有关。过去认为神经元在神经病理性疼痛的发生发展中起主要作用,但目前大量研究揭示胶质细胞同样参与神经病理性疼痛的发生,其中嘌呤信号介导神经元-胶质细胞相互作用作为神经病理性疼痛的关键机制之一。该文就嘌呤受体在神经病理性疼痛中的作用进行综述。

Neuropathic pain has been redefined by NeuPSIG as“pain arising as a direct consequence of a lesion or disease affecting the somatosensory syste”.However,pharmacological management for neuropathic pain is not effective,which is correlated with the uncertainty of pathogenesis.For a long time,neuron had been considered acting a major role in the development of neuropathic pain.In recent years,a majority of studies revealed that glia cell also involved in the occurrence and development of neuropathic pain,and neuron-glia interaction is one of the key mechanism of neuropathic pain,including complex signaling pathways as purinergic signaling.This review focuses on recent advances on the role of purinergic receptors in neuropathic pain.