慢性阻塞性肺疾病早期诊断相关标志物研究进展

Research progress of relevant markers for early diagnosis of chronic obstructive pulmonary disease

慢性阻塞性肺疾病是一组具有多表型的异质性疾病,吸烟是疾病进展的重要危险因素。慢性阻塞性肺疾病早期阶段一般是指轻/中度慢性阻塞性肺疾病,多数患者在此阶段无明显临床表现,就医意识淡薄。因此,诊断相关生物标志物的研究有助于慢性阻塞性肺疾病的早期防治,进而延缓肺功能下降速度,减少医疗费用和降低死亡风险。该文对近5年来与慢性阻塞性肺疾病早期诊断标志物相关的研究进行总结。

Chronic obstructive pulmonary disease is a group of heterogeneous diseases with multiple phenotypes.Smoking is an important risk factor for disease progression.The early stage of chronic obstructive pulmonary disease generally refers to mild/moderate chronic obstructive pulmonary disease.Most patients have no obvious clinical manifestations at this stage,and their seek medical awareness is weak.Therefore,the research of diagnosis-related biomarkers is helpful to the early prevention and treatment of chronic obstructive pulmonary disease,thereby delaying the decline of lung function,reducing medical expenses and reducing the risk of death.This article summarizes the research related to early diagnosis markers of chronic obstructive pulmonary disease in the past 5 years.