血清IL-17、TGF-β_(1)水平对乳腺癌改良根治术后复发的影响

Effect of Serum Il-17 and TGF-β_(1) Levels on Recurrence of Breast Cancer After Modified Radical Mastectomy

目的探讨血清白细胞介素-17(IL-17)、转化生长因子-β_(1)(TGF-β_(1))水平对乳腺癌改良根治术后复发的影响。方法收集2019年1月至2020年6月商丘市第三人民医院收治的74例乳腺癌改良根治术后复发患者(复发组)的临床资料,另选取同期74例未复发(未复发组)患者临床资料,比较两组患者一般资料及术前血清IL-17、TGF-β_(1)水平,分析血清IL-17、TGF-β_(1)水平与乳腺癌患者改良根治术后复发的关系。结果复发组TNMⅢ期患者占比高于未复发组,肿瘤直径大于未复发组,术前血清IL-17、TGF-β_(1)水平高于未复发组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,TNM分期为Ⅲ期、肿瘤最长直径较长、血清IL-17和TGF-β_(1)过表达对乳腺癌患者改良根治术后复发有一定影响(OR>1,P<0.05)。结论血清IL-17、TGF-β_(1)过表达与乳腺癌患者改良根治术后复发关系密切。

Objective To investigate the effect of serum interleukin-17(IL-17)and transforming growth factor-β_(1)(TGF-β_(1))levels on the recurrence of breast cancer after modified radical mastectomy.Methods The clinical data of 74 patients(recurrence group)who had recurrence after modified radical mastectomy treated in Shangqiu Third People’s Hospital from January 2019 to June 2020 were collected,and the clinical data of 74 patients(non recurrence group)who did not have recurrence in the same period were selected.The general data of patients and the levels of serum IL-17 and TGF-β_(1) before operation were consulted and recorded,the relationship between serum IL-17 and TGF-β_(1) levels and recurrence after modified radical mastectomy in patients with breast cancer was analyzed.Results The proportion of TNM stageⅢpatients in the recurrence group was higher than that in the non recurrence group,the tumor diameter was larger than that in the non recurrence group,and the preoperative serum levels of IL-17 and TGF-β_(1) were higher than those in the non recurrence group,with statistical significant differences(P<0.05).Logistic regression analysis showed that TNM stageⅢ,longer longest diameter of tumor,over expression of serum IL-17 and TGF-β_(1) might have effect on recurrence in patients with breast cancer modified radical mastectomy(OR>1,P<0.05).Conclusion Serum IL-17and TGF-β_(1) overexpression is closely related to recurrence after modified radical mastectomy.