VOCs采集与分析技术在肺癌诊疗中的研究进展

Advances on Collection and Analysis of Volatile Organic Compounds in the Diagnosis of Lung Cancer

肺癌是全球范围内发病率和死亡率最高,对人群健康和生命威胁最大的恶性肿瘤之一。筛查与早诊早治是降低人群肺癌死亡率的有效措施。挥发性有机化合物(volatile organic compounds,VOCs)检测以快捷性、无创性、采样方便成为一种具有广泛前景的检测手段,可用于肺癌的早期发现,病程检测及预后管理。目前国内外涌现出了多种VOCs采集设备及分析技术,本综述主要从VOCs采集技术、分析技术以及在肺癌诊疗中的应用研究进展三方面探讨VOCs研究目前所存在的问题及研究前景。

Lung cancer is a leading cause of cancer-related morbidity and mortality globally,which is the biggest menace to the health and life of the population.Screening and early detection of lung cancer are effective in reducing its mortality,and the measurement of volatile organic compounds(VOCs)has become a promising clinical means for early detection,course detection and prognosis management of lung cancer,with advantages of rapid speed,non-invasiveness and convenience.Now,a variety of VOCs collection ways and analysis methods have emerged at home and abroad.This report summarized three aspects,including VOCs collection,multiple methods of analysis and progress in the diagnosis and treatment of lung cancer.At last,we discussed the limitations and prospects of VOCs analysis.