摘要
Glioma is the most common primary malignant brain tumor with a poor survival rate.In recent years,no significant progress has been made in the treatment of gliomas in contrast to the development of improved diagnosis via molecular typing.Newcastle disease virus(NDV),a negative-stranded RNA virus that exhibits oncolytic activity,has been investigated for its capacity to elicit antitumor activity in many types of cancers,including glioma.Therefore,application of oncolytic viruses,such as NDV,as a new treatment strategy to specifically target aberrant signaling in glioblastomas has brought new hope.For many years,NDV has been investigated for its in vivo and in vitro efficacy in the treatment of various tumor cells.Based on its safety in humans,specificity for tumor cells,and immunostimulatory properties,NDV represents a promising antitumor agent.In this review,we summarize the background of NDV and the antitumor mechanisms of NDV-mediated oncolysis,discuss the potential value and role of NDV in gliomas,and describe new advances and perspectives for future research.
出处
《BIOCELL》
SCIE
2019年第3期119-127,共9页
生物细胞（英文）
基金
supported by the National Science Foundation of Liaoning Province(No.20180530059)
Guiding Funds for the Development of Local Science and Technology by the Central Government(No.2017106014)
The Key Research and Development Project of Liaoning Province(No.2018225040).
