固尔苏、氨溴索分别联合经鼻持续气道正压通气治疗新生儿呼吸窘迫综合征的疗效及安全性

Efficacy and safety of curosurf,ambroxol combined with nosal continous positive airway pressure in the treatment of neonatal respiratory distress syndrome

目的探讨固尔苏、氨溴索分别联合经鼻持续气道正压通气(nCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效及安全性。方法选择2019年2月至2020年2月在惠东县人民医院治疗的60例NRDS患儿为研究对象,根据随机数表法将患儿分为观察组和对照组各30例,对照组患儿采用氨溴索联合nCPAP治疗,观察组患儿采用固尔苏联合nCPAP治疗。比较两组患儿治疗24 h后的治疗效果,治疗前及治疗后24 h的动脉血气指标,氧合指数(OI)、平均气道压(MAP)水平和治疗后并发症发生情况。结果观察组患儿的治疗总有效率为96.67%,明显高于对照组的66.67%,差异有统计学意义(P<0.05);治疗后,观察组患儿的PaO2水平、pH值分别为(75.86±10.29) mmHg、(7.36±0.10),明显高于对照组的(69.21±9.07) mmHg、(7.23±0.09),PaCO2水平为(46.02±10.89) mmHg,明显低于对照组的(53.28±11.06) mm Hg,差异均有统计学意义(P<0.05);治疗后,观察组患儿的OI水平为(279.30±19.65) mmHg,明显高于对照组的(232.83±15.76) mm Hg,MAP水平为(6.51±1.39) cmH2O,明显低于对照组的(7.92±1.57) cmH2O,差异均有统计学意义(P<0.05);两组患儿的并发症发生率比较差异无统计学意义(P>0.05)。结论固尔苏联合nCPAP治疗NRDS的效果高于氨溴索,其可有效改善患儿的通气功能,临床疗效显著。

Objective To study the efficacy and safety of curosurf,ambroxol combined with nosal continous positive airway pressure(nCPAP) in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 60 patients with NRDS who received treatment in Huidong County People’s Hospital from February 2019 to February2020 were selected for this study.According to random number table method,the patients were divided into the study group and control group,with 30 patients in each group.The control group was treated with ambroxol combined with nCPAP,and the study group was treated with curosurf combined with nCPAP.The therapeutic effects of the two groups after 24 hours of treatment,arterial blood gas index,Oxygenation(OI),mean airway pressure levels before and 24 hours after treatment and complications were compared between the two groups.Results The total effective rate of the study group was 96.67%,which was significantly higher than 66.67% of the control group(P<0.05);after treatment,the PaO2 level and p H value of study group were respectively(75.86±10.29) mm Hg and 7.36±0.10,which were significantly higher than corresponding(69.21 ± 9.07) mm Hg,7.23 ± 0.09 of the control group(P<0.05);the Pa CO2 level of study group was(46.02±10.89) mm Hg,which was significantly lower than(53.28±11.06) mm Hg of the control group(P<0.05);after treatment,the OI level of study group was(279.30±19.65) mm Hg,which was significantly higher than(232.83±15.76) mm Hg of the control group(P<0.05);the MAP level of study group was(6.51±1.39) cm H2 O,which was significantly lower than(7.92±1.57) cm H2 O of the control group(P<0.05);there was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Curosurf combined with n CPAP is more effective than ambroxol in the treatment of NRDS,and it can effectively improve the ventilation function of children with significant clinical efficacy.