补气健骨汤联合福善美治疗骨质疏松症疗效观察

Effect of Buqi Jiangu Decoction combined with Alendronate Sodium Tablets in the treatment of osteoporosis

目的观察补气健骨汤配联合福善美治疗骨质疏松症的临床效果。方法选取2017年1月至2019年12月南京市中医院骨伤科收治的80例骨质疏松症患者纳入研究,按随机数表法将其分为观察组和对照组,每组40例,对照组在常规治疗的基础上采用福善美治疗,观察组在对照组治疗的基础上采用补气健骨汤治疗,疗程12周。12周后比较两组患者的临床疗效,治疗前后血清中Ⅰ型前胶原C-端前肽(PICP)、Ⅰ型胶原C-末端肽(CTX)、骨钙素(OC)水平,腰椎L1~4、股骨颈、大粗隆骨密度及不良反应情况。结果观察组患者的治疗总有效率为95.0%,明显高于对照组的77.5%,差异有统计学意义(P<0.05);治疗后,两组患者的PICP、OC均明显提高,CTX均明显降低,且观察组患者的PICP和OC分别为(168.43±26.82)μg/L、(7.15±1.71)μg/L,明显高于对照组的(142.67±21.35)μg/L、(6.05±0.98)μg/L,CTX为(0.21±0.08)ng/mL,明显低于对照组的(0.37±0.10)ng/mL,差异均有统计学意义(P<0.05);治疗后,两组患者的股骨颈、腰椎L1~4、大粗隆骨的骨密度均明显高于治疗前,且观察组上述各项指标明显高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的不良反应发生率为7.5%,略低于对照组的15.0%,但差异无统计学意义(P>0.05)。结论与单独使用福善美治疗骨质疏松症相比,补气健骨汤联合福善美治疗可调节患者骨代谢相关指标,改善骨密度及骨质疏松症状,有助于提高患者的临床疗效。

Objective To observe the clinical efficiency of Buqi Jiangu Decoction combined with Alendronate Sodium Tablets(Fushanmei)in the treatment of osteoporosis.Methods Eighty patients with osteoporosis admitted to the Department of Orthopedics at Nanjing Hospital of Traditional Chinese Medicine from January 2017 to December2019 were selected and divided into an observation group and a control group according to the random number table method,with 40 patients in each group.The control group received basic treatment and Alendronate Sodium Tablets treatment,and the observation group was treated with Buqi Jiangu Decoction on the basis of the control group.The course of treatment was 12 weeks.The clinical curative effects of the two groups were compared after 12 weeks,as well as the serum levels of procollagen I C-terminal peptide(PICP),collagen type I C-terminal telopeptide(CTX),osteocalcin(OC)before and after treatment;and the bone mineral density of the lumbar vertebrae L1~4,femoral neck,and greater trochanter,as well as adverse reactions,were also compared before and after treatment in the two groups.Results The total effective rate was 95.0%in the observation group,which was significantly higher than 77.5%in the control group(P<0.05).After treatment,the PICP and OC of the two groups were significantly increased,and the CTX was significantly reduced.The PICP and OC levels of the observation group were(168.43±26.82)μg/L and(7.15±1.71)μg/L,respectively,which were significantly higher than corresponding(142.67±21.35)μg/L and(6.05±0.98)μg/L of the control group(P<0.05);and CTX level was(0.21±0.08)ng/mL in the observation group,which was significantly lower than(0.37±0.10)ng/mL in the control group(P<0.05).After treatment,the bone mineral density of the femoral neck,lumbar vertebrae L1~4,and greater trochanter of the two groups were significantly higher than those before treatment(P<0.05),and the above-mentioned indicators were all significantly higher in the observation group than in the control group(P<0.05).After treatment,the incidence of adverse reactions was 7.5%in the observation group,which was slightly lower than 15.0%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Compared with the use of Alendronate Sodium Tablets alone in the treatment of osteoporosis,combination of Buqi Jiangu Decoction and Alendronate Sodium Tablets can adjust the bone metabolism related indicators,improve bone density and osteoporosis symptoms,and help improve the clinical efficacy of patients.