自噬参与糖尿病血管病变的研究进展

Role of autophagy in the progression of diabetic angiopathy

糖尿病血管病变是糖尿病较严重的慢性并发症之一。在高糖状态下,血管正常功能受到损害的同时常常会引起一系列血管并发症,如:糖尿病视网膜病变、糖尿病肾病、下肢动脉硬化闭塞、主动脉瘤等。而近来的研究表明,自噬作为一种细胞内蛋白质降解途径和一种机体防御机制,在糖尿病血管病变中发挥着重要作用。此文章综述了自噬相关分子、糖尿病自噬调控途径以及自噬在糖尿病相关血管病变中的不同作用,并对自噬参与糖尿病血管病变的机制进行了深入探讨,提出了靶向自噬的机制研究可能会开辟一个新的治疗糖尿病血管病变途径的学说。

Diabetic angiopathy is one of the most serious complications of diabetes. In a state of high glucose, normal functions of blood vessels are damaged, which leads to a series of vascular complications such as diabetic retinopathy, diabetic nephropathy, lower extremity arteriosclerosis occlusion and aortic aneurysm. However, recent studies have revealed that autophagy as an intracellular protein degradation pathway and stress defense mechanism, plays a significant role in the progression of diabetic angiopathy. Thus, we have summarized the progress on research with respect to autophagy-related genes, autophagy signaling pathways and the roles of autophagy in diabetic angiopathy and discuss the detailed mechanisms, which may provide treatment options for diabetic angiopathy.