度洛西汀在术后镇痛中的应用

Application of duloxetine in postoperative analgesia

度洛西汀是一种5-羟色胺和去甲肾上腺素再摄取抑制药,近年有学者探索其用于术后镇痛。但由于度洛西汀的药理特性,可能引起术中高血压、出血增加、影响围术期药物代谢等,其用法相对保守。本文对现有研究中度洛西汀用于手术患者的作用机制、用药方案、不良反应等进行阐述,综合分析现有研究结果,以期为该药物的安全、高效应用提供参考。

Duloxetine,a serotonin and norepinephrine reuptake inhibitor,has been used for postoperative acute and subacute pain by researchers in recent years.However,it may cause intraoperative hypertension and increased bleeding due to the pharmacological properties of duloxetine.And the drug interactions can affect pharmacodynamics and pharmacokinetics of common drugs perioperatively used.Therefore,the use of duloxetine for surgical patients is conservative.This review focuses on the purposes,mechanisms,medication regimens and adverse reactions of the use of duloxetine for surgical patients in recent studies in order to provide valuable references for efficient and safe application.