舍曲林联合低频重复经颅磁刺激对首发重度抑郁患者炎症因子水平的影响

Effect of Sertraline Combined with Low-frequency Repetitive Transcranial Magnetic Stimulation on the Levels of Inflammatory Factors in Patients with First-episode Severe Depression

目的:探讨舍曲林联合低频重复经颅磁刺激对首发重度抑郁患者炎症因子水平的影响。方法:选择2020年6月1日-2021年2月28日东莞市第七人民医院收治的首发重症抑郁发作患者50例。采用随机数字表法将其分为研究组与对照组,每组25例。对照组采用单用舍曲林治疗,研究组采用舍曲林联合低频重复经颅磁刺激治疗。治疗1、4、8周后,检测两组白细胞计数(WBC)、纤维蛋白原(FIB)、C反应蛋白(CRP)、超敏C反应蛋白(hs-CRP)、白蛋白(ALB)等指标。比较两组HAMD评分。结果:治疗前,两组WBC、ALB、FIB、CRP、hs-CRP、HAMD评分比较差异无统计学意义(P>0.05);治疗后,两组FIB、CRP、hs-CRP、WBC、HAMD评分均较治疗前显著降低,ALB均较治疗前显著升高,且随着治疗时间延长,FIB、CRP、hs-CRP、WBC、HAMD评分逐渐降低,ALB逐渐升高(P<0.05)。治疗1、4、8周后,研究组FIB、CRP、hs-CRP、WBC、HAMD评分均显著低于对照组,ALB均显著高于对照组,差异有统计学意义(P<0.05)。结论:舍曲林联合低频重复经颅磁刺激能改善首发重度抑郁患者炎症因子水平,明显降低重度抑郁症患者HAMD评分,改善抑郁症状。低频重复经颅磁刺激治疗具有增效作用。

Objective:To explore the effect of Sertraline combined with low-frequency repetitive transcranial magnetic stimulation on the levels of inflammatory factors in patients with first-episode severe depression.Method:Fifty patients with first-episode severe depression admitted in the Seventh People’s Hospital of Dongguan from June 1st,2020 to February 28th,2021 were selected.They were divided into the study group and the control group by random number table method,with 25 cases in each group.The control group was treated with Sertraline alone,and the study group was treated with Sertraline combined with low-frequency repetitive transcranial magnetic stimulation.After 1,4 and 8 weeks of treatment,white blood cell count (WBC),fibrinogen (FIB),C-reactive protein (CRP),hypersensitive C-reactive protein (hs-CRP),albumin (ALB) indicators in both groups were detected.HAMD score was compared between the two groups.Result:Before treatment,there were no significant differences in WBC,ALB,FIB,CRP,hs-CRP and HAMD scores between the two groups (P>0.05).After treatment,FIB,CRP,hs-CRP,WBC and HAMD scores in both groups were significantly reduced compared with those before treatment,while ALB were significantly increased compared with that before treatment,and FIB,CRP,hs-CRP,WBC and HAMD gradually decreased with the extension of treatment time,and ALB was gradually increased (P<0.05).After 1,4 and 8 weeks of treatment,FIB,CRP,hs-CRP,WBC and HAMD scores in the study group were significantly lower than those in the control group,while ALB was significantly higher than that in the control group,the differences were statistically significant (P<0.05).Conclusion:Sertraline combined with low-frequency repetitive transcranial magnetic stimulation can improve the levels of inflammatory factors in patients with first-episode major depression,significantly reduce the HAMD score of patients with major depression,and improve depressive symptoms.Low-frequency repetitive transcranial magnetic stimulation has a synergistic effect.