阿司匹林联合氯吡格雷治疗穿支动脉闭塞性脑梗死患者的效果及对血清FIB、Hcy水平影响

Effect of Aspirin Combined with Clopidogrel in the Treatment of Perforator Artery Occlusive Cerebral Infarction and Its Influence on Serum FIB,Hcy Levels

目的:探讨阿司匹林联合氯吡格雷治疗穿支动脉闭塞性脑梗死患者的效果及对血清纤维蛋白原(FIB)、同型半胱氨酸(Hcy)水平影响。方法:选择2018年2月-2020年5月穿支动脉闭塞性脑梗死患者68例,随机分为两组,各34例。对照组给予阿司匹林治疗,观察组联合氯吡格雷治疗,两组均治疗14 d。比较两组治疗效果、神经功能缺损评分标准(CSS)、Barthel指数(BI)评分及FIB、Hcy水平。结果:观察组治疗后7 d总有效率为94.12%,高于对照组的73.53%,差异有统计学意义(P<0.05)。两组治疗后CSS水平低于治疗前(P<0.05),BI评分高于治疗前(P<0.05);观察组治疗后CSS评分低于对照组,BI高于对照组(P<0.05)。两组治疗后14 d血清FIB、Hcy水平均低于治疗前(P<0.05),观察组治疗后14 d血清FIB、Hcy水平均低于对照组(P<0.05)。结论:阿司匹林联合氯吡格雷用于穿支动脉闭塞性脑梗死患者中能减轻患者神经损伤,同时能降低患者血清内FIB、Hcy水平,能够有效改善患者病症,值得推广应用。

Objective:To investigate the effect of Aspirin combined with Clopidogrel in the treatment of perforator artery occlusive cerebral infarction and its influence on serum fibrinogen(FIB),homocysteine(Hcy)levels.Method:A total of 68 patients with perforating artery occlusion cerebral infarction from February 2018 to May 2020 were selected and randomly divided into two groups,34 cases in each group.The control group was treated with Aspirin,and the observation group was combined with Clopidogrel.Both groups were treated for 14 days.The treatment effect,neurological impairment score(CSS),Barthel index(BI)score and serum FIB and Hcy levels of the two groups were compared.Result:The total effective rate of the observation group was 94.12%on 7 days after treatment,which was higher than 73.53%of the control group,the difference was statistically significant(P<0.05).The CSS level of the two groups after treatment was lower than that before treatment(P<0.05),the BI score was higher than that before treatment(P<0.05);the CSS score of the observation group after treatment was lower than that of the control group,the BI was higher than that of the control group(P<0.05).The serum FIB and Hcy levels of the two groups 14 days after treatment were lower than those before treatment(P<0.05);the levels of serum FIB and Hcy in the observation group were lower than those in the control group 14 days after treatment(P<0.05).Conclusion:Aspirin combined with Clopidogrel in patients with perforating artery occlusion cerebral infarction can reduce the nerve injury,and can reduce the levels of serum FIB and Hcy,which can effectively improve the symptoms of patients,and is worthy of popularization and application.