APACG黄斑区脉络膜厚度及其影响因素分析

Results of Macular Choroidal Thickness and Analysis of Influence Factors in Patients with Acute Primary Angle-Closure Glaucoma

目的:分析原发性急性闭角型青光眼(APACG)黄斑区脉络膜厚度及其影响因素。方法:回顾性分析2019年1月-2020年12月在本科诊治的107例APACG患者的临床资料,将其设为研究组,其中急性发作眼107眼和对侧临床前期眼107眼。另选110例(110眼)于同时期来本院眼科行白内障手术的患者为对照组,比较两组黄斑区脉络膜厚度差异。将研究组急性发作眼中脉络膜增厚(75例,75眼)的患者分为A组,脉络膜未增厚或变薄(32例,32眼)的患者分为B组。分析黄斑区脉络膜增厚的影响因素。结果:研究组急性发作眼的黄斑区脉络膜厚度均大于研究组临床前期眼和对照组,差异均有统计学意义(P<0.05)。A组、B组眼别、晶体厚度比较,差异均无统计学意义(P>0.05)。A组、B组年龄、性别、眼压、眼轴长度、前房深度、屈光度比较,差异均有统计学意义(P<0.05)。Logistic回归分析显示,眼压、年龄、眼轴长度均为APACG急性发作眼黄斑脉络膜厚度的保护因素(P<0.05)。结论:原发急性青光眼患者的黄斑区脉络膜可膨胀增厚,眼压、年龄、眼轴长度均可影响APACG患者的黄斑区脉络膜厚度。

Objective:To analyze the results and influence factors of macular choroidal thickness in patients with acute primary angle-closure glaucoma (APACG).Method:The clinical data of 107 patients with APACG diagnosed and treated in our department from January 2019 to December 2020 were retrospectively analyzed,they were selected as the study group,and there were 107 eyes with acute attack eyes and 107 eyes with contralateral preclinical eyes.Another 110 patients (110 eyes) who underwent cataract surgery in our hospital at the same time were selected as the control group,and the difference of choroid thickness was compared between two groups.Patients with acute choroid thickening (75 cases,75 eyes) were divided into group A and patients without choroid thickening or thinning (32 cases,32 eyes) were divided into group B.The influencing factors of choroid thickening in macular region were analyzed.Result:The thickness of choroid in macular area of acute attack eyes in the study group was higher than that in the contralateral preclinical eyes in the study group and control group,the differences were statistically significant (P<0.05).There were no significant differences in eye size and crystal thickness between group A and group B (P>0.05).There were statistically significant differences in age,gender,intraocular pressure,axial length,anterior chamber depth and diopter between group A and group B (P<0.05).Logistic regression analysis showed that intraocular pressure,age and axial length were all protective factors for macular choroid thickness in APACG (P<0.05).Conclusion:The macular choroid of patients with acute primary glaucoma can expand and thicken.Intraocular pressure,age and axial length can affect the macular choroidal thickness of patients with primary acute angle-closure glaucoma.