细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群表达水平与预后相关性分析

Correlation between expression levels of peripheral blood T lymphocyte subsets and prognosis in patients with bacterial liver abscess and type 2 diabetes

目的:探讨细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群表达水平与预后的相关性。方法:选取细菌性肝脓肿患者66例作为研究对象,根据是否合并2型糖尿病分为合并组(26例)和非合并组(40例)。比较两组患者白细胞计数、空腹血糖、餐后2 h血糖、T淋巴细胞亚群水平以及预后情况。分析T淋巴细胞亚群表达水平与患者预后的相关性。结果:合并组患者白细胞计数、空腹血糖、餐后2 h血糖高于非合并组(均P<0.05)。合并组患者CD3^(+)与CD4^(+)T淋巴细胞水平低于非合并组(均P<0.05)。治疗后3个月,合并组预后良好者占比为76.9%,低于对照组的97.5%(P<0.05)。Spearman相关性分析显示,患者预后与CD3^(+)、CD4^(+)T淋巴细胞水平存在相关性(r_(s)=0.644、0.582,均P<0.05)。二分类Logistic回归分析显示,CD3^(+)、CD4^(+)T淋巴细胞水平为影响患者预后的重要因素(均P<0.05)。结论:细菌性肝脓肿合并2型糖尿病患者外周血T淋巴细胞亚群水平下降,预后变差;CD3^(+)、CD4^(+)T淋巴细胞水平为影响患者预后的重要因素。

Objective:To investigate the correlation between expression levels of peripheral blood T lymphocyte subsets and prognosis in patients with bacterial liver abscess and type 2 diabetes.Methods:A total of 66 patients with bacterial liver abscess were selected as the research objects,and they were divided into combined group(26 cases)and non-combined group(40 cases)according to whether they had type 2 diabetes.The white blood cell count,fasting blood glucose,postprandial 2-hour blood glucose,T lymphocyte subsets levels,and prognosis were compared between the two groups.The correlation between the expression levels of T lymphocyte subsets and the prognosis of patients was analyzed.Results:The white blood cell count,fasting blood glucose,and postprandial 2-hour blood glucose in the combined group were higher than those in the non-combined group(all P<0.05).The levels of CD3^(+)and CD4^(+)T lymphocytes in the combined group was lower than that in the non-combined group(all P<0.05).Three months after treatment,the proportion of patients with good prognosis in the combined group was 76.9%,which was lower than 97.5%in the control group(P<0.05).Spearman correlation analysis showed that the prognosis of patients was correlated with the levels of CD3^(+)and CD4^(+)T lymphocytes(r_(s)=0.644,0.582,both P<0.05).The binary Logistic regression analysis showed that the levels of CD3^(+)and CD4^(+)T lymphocytes were important factors affecting the prognosis of patients(all P<0.05).Conclusion:The levels of T lymphocyte subsets in peripheral blood of patients with bacterial liver abscess and type 2 diabetes decreases,and the prognosis becomes worse.The levels of CD3^(+)and CD4^(+)T lymphocytes are important factors affecting the prognosis of patients.