纤溶酶对脑梗死急性期患者APTT、PT及血液流变学的影响与神经功能恢复的评价研究

Effect of Plasmin on APTT, PT and Hemorheology in Patients with Acute Cerebral Infarction and Evaluation of Neurological Recovery

目的探讨纤溶酶对脑梗死急性期患者活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)与血液流变学的影响。方法选取我院2017年1月至2020年12月收治的150例脑梗死急性期患者作为研究对象,分为观察组(纤溶酶+常规治疗)和对照组(常规治疗)各75例,比较两组患者的治疗效果。结果观察组患者的APTT[(28.19±2.04)s vs.(25.37±1.57)s,t=9.487]、PT[(12.35±1.07)s vs.(10.86±1.43)s,t=7.225]、简式Fugl-Meyer运动功能评分[(85.54±6.22)分vs.(80.23±4.06)分,t=6.205]均高于对照组(P <0.05),观察组患者在治疗后的全血黏度[(3.86±0.50)m Pa/s vs.(4.34±0.54)m Pa/s,t=5.648]、血浆黏度[(1.45±0.33)m Pa/s vs.(1.60±0.39)m Pa/s,t=2.543]以及神经缺损程度(NIHSS)评分[(6.41±2.05)分vs.(8.28±1.97)分,t=5.696]均低于对照组(P <0.05)。结论在脑梗死急性期的临床治疗中,纤溶酶的应用对于患者APTT、PT与血液流变学等指标的快速、良好改善有着积极的影响。

Objective To investigate the effects of plasmin on activated partial thromboplastin time(APTT), plasma prothrombin time(PT) and hemorheology in patients with acute cerebral infarction. Methods 150 patients with acute cerebral infarction treated in our hospital from January 2017 to December 2020 were divided into observation group(plasmin + routine treatment) and control group(routine treatment), with 75 cases in each group. The therapeutic effects of the two groups were compared. Results APTT [(28.19±2.04) s vs.(25.37±1.57) s, t=9.487], PT [(12.35±1.07) s vs.(10.86±1.43) s, t =7.225] and simple Fugl-Meyer motor function score [(85.54±6.22) vs.(80.23±4.06), t =6.205] in the observation group were higher than those in the control group(P <0.05). The whole blood viscosity [(3.86±0.50) mPa/s vs.(4.34±0.54) mPa/s in the observation group after treatment, t =5.648],plasma viscosity [(1.45±0.33) mPa/s vs.(1.60 ± 0.39) mPa/s, t =2.543] and NIHSS score [(6.41±2.05) vs.(8.28±1.97), t =5.696] were lower than those in the control group(P <0.05). Conclusion In the clinical treatment of acute cerebral infarction, the application of plasmin has a positive impact on the rapid and good improvement of APTT, PT and hemorheology.