药物涂层球囊治疗下肢动脉硬化闭塞症效果观察

Effect observation of drug-coated balloon on ASO patients

目的探讨药物涂层球囊(Drug-coated balloon,DCB)治疗下肢动脉硬化闭塞症(Atherosclerosis obliterrans,ASO)的效果。方法选择本院2017年10月至2019年9月收治的ASO患者127例,根据治疗方式不同分为对照组63例和观察组64例。对照组给予普通球囊(Plain of balloon angioplasty,POBA)治疗,观察组采用POBA和DCB治疗,观察两组靶血管通畅率、动脉管腔直径、踝肱指数、远期效果及并发症情况。结果观察组术后6月末、12月末靶血管一期通畅率均高于对照组(P<0.05)。两组术后12月末最小管腔直径(Minimal lumen diameter,MLD)、踝肱指数(Ankle branch index,ABI)水平较术前均升高,且观察组高于对照组(P<0.05)。观察组术后6月末、12月末晚期管腔丢失量(Late lumen loss,LLL)、靶病变血运重建(Target lesion revascularization rate,TLR)率水平均低于对照组(P<0.05)。观察组并发症发生率与对照组相比,差异无统计学意义(P>0.05)。结论DCB治疗ASO患者效果确切,通过持续作用于血管内皮细胞以改善靶血管通畅率,调节ABI水平,调控动脉管腔直径水平及远期效果,降低术后并发症的发生,提高临床疗效。

Objective To investigate the efficacy of drug-coated balloon(DCB)in the treatment of ASO.Methods A total of 127 ASO patients in our hospital from October 2017 to September 2019 were selected as research objects and divided into control group(n=63)and observation group(n=64).The control group was treated with plain of ballon angioplasty(POBA),while the observation group was treated with POBA and DCB.Target vessel unobligation rate,arterial lumen diameter,ankle-brachial index,long-term effect,and complications in the two groups were observed.Results The primary patency rates of target vessels in the observation group at the end of 6 months,12 months after operation were higher than those in the control group(P<0.05).At the end of 12 months after operation,the MLD and ABI levels of both groups were increased compared with those before operation,and the observation group was higher than the control group(P<0.05).At the end of 6 months,12 months after operation,the level of lumen loss(LLL)and TLR rate of target lesion in the observation group were lower than those in the control group(P<0.05).The complication rate of the observation group was lower than that of the control group(P>0.05).Conclusion DCB has a definite effect on ASO patients.By continuously acting on vascular endothelial cells,it can improve target vessel patent rate,regulate ABI level,regulate arterial lumen diameter level and long-term effect,reduce the occurrence of postoperative complications,and improve clinical efficacy.