探讨草酸艾司西酞普兰与盐酸帕罗西汀治疗抑郁症患者的临床疗效比较

Compare the Clinical Efficacy of escitalopram Oxalate and Paroxetine Hydrochloride in the Treatment of Depression

目的对比分析抑郁症患者采取草酸艾司西酞普兰与盐酸帕罗西汀治疗效果。方法本次试验120例抑郁症患者均为本院接收治疗,时间为2018年5月至2019年4月,根据入院单号、双号分为两组,对照组(n=60)与研究组(n=60)分别开展盐酸帕罗西汀与草酸艾司西酞普兰治疗方案,统计各组临床治疗效果及不良反应发生率,并评估患者治疗前后抑郁评分。结果在治疗总有效率及不良反应发生率方面,对照组分别是81.67%和15.00%,研究组分别是95.00%和3.33%,研究组相比于对照组更优(P<0.05);在HAMD评分方面,治疗前,两组比较无差异(P>0.05);治疗后,研究组较对照组更低(P<0.05);在MADRS评分及PSQI评分,治疗前,两组比较无差异(P>0.05);治疗后,研究组较对照组更优(P<0.05)。结论抑郁症疾病治疗过程中,草酸艾司西酞普兰较盐酸帕罗西汀更优,不仅可以缓解抑郁症状,同时可促进治疗效果提高,而且安全性高,为患者的疾病治疗提供了保障,临床上可加大应用力度。

Objective To compare the therapeutic effects of escitalopram oxalate and paroxetine hydrochloride in patients with depression.Methods One hundred and twenty patients with depression were admitted to our hospital from May 2018 to April 2019.They were divided into two groups according to the admission order number and double number.The control group(n=60)and the study group(n=60)were given paroxetine hydrochloride and escitalopram oxalate,respectively.Depression scores were assessed before and after treatment.Results The total effective rate and the incidence of adverse reactions were 81.67%and 15.00%in the control group and 95.00%and 3.33%in the study group,respectively.The study group was better than the control group(P<0.05).In terms of HAMD score,there was no statistical significance between the two groups before treatment(P>0.05).After treatment,the study group was lower than the control group(P<0.05).Before treatment,there was no significant difference in MADRS score and PSQI score between the two groups(P>0.05).After treatment,the study group was better than the control group(P<0.05).Conclusion Escitalopram oxalate is better than paroxetine hydrochloride in the treatment of depression,which can not only relieve the symptoms of depression,but also promote the improvement of the treatment effect,and has high safety,which provides a guarantee for the treatment of patients,and can be more clinically applied.