胃癌术前外周血NLR、PLR、FIB与术后发生卵巢转移时间的相关性分析

Correlation Analysis Between Preoperative Peripheral Blood NLR,PLR,FIB and Postoperative Ovarian Metastasis Time of Gastric Cancer

目的探索胃癌患者胃原发灶切除手术前外周血中性粒细胞/淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、血浆纤维蛋白原水平(FIB)及临床病理特征与术后发生卵巢转移时间的相关性。方法回顾性分析2016年1月-2019年9月安徽省立医院收治的胃癌术后发生卵巢转移患者49例的临床病理资料,分析其外周血NLR、PLR、FIB及临床病理特征与胃癌原发灶手术至术后发生卵巢转移时间的相关性。结果所有患者胃癌原发灶切除手术时间至首次发生卵巢转移的中位时间为19.43个月;单因素分析显示,不同年龄、原发灶部位、原发灶大小、T分期、N分期、手术方式、术前PLR的患者手术至卵巢转移时间比较,差异无统计学意义(P>0.05);弥漫型胃癌、术前高NLR、术前高FIB水平的患者手术至卵巢转移时间短于肠型胃癌、术前低NLR、术前低FIB水平的患者,差异有统计学意义(P<0.05);多因素分析显示,原发灶Lauren分型、术前外周血NLR是影响胃癌术后发生卵巢转移时间的独立影响因素。结论胃癌患者术前外周血NLR升高、FIB升高及弥漫型胃癌患者可能发生卵巢转移的时间较早,胃癌原发灶术后Lauren分型、术前外周血NLR可能是影响胃癌术后发生卵巢转移的独立危险因素。

Objective To explore the correlation between peripheral blood neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),plasma fibrinogen level(FIB),clinical pathological features and postoperative ovarian metastasis time in patients with gastric cancer before gastrectomy.Methods The clinicopathological data of 49 patients with ovarian metastasis after gastric cancer surgery admitted to Anhui Provincial Hospital from January 2016 to September 2019 were retrospectively analyzed.The correlation between peripheral blood NLR,PLR,FIB and clinicopathological characteristics and the time of ovarian metastasis from primary gastric cancer surgery to postoperative was analyzed.Results The median time from resection of primary gastric cancer to the first occurrence of ovarian metastasis in all patients was 19.43 months;univariate analysis showed that there was no significant difference in the time from surgery to ovarian metastasis among patients with different ages,primary sites,primary sizes,T staging,N staging,surgical methods,and preoperative PLR(P>0.05).Patients with diffuse gastric cancer,preoperative high NLR and preoperative high FIB had shorter ovarian metastasis time than those with intestinal gastric cancer,preoperative low NLR and preoperative low FIB,and the differences were statistically significant(P<0.05).Multivariate analysis showed that Lauren classification of primary tumor and preoperative peripheral blood NLR were independent factors affecting the time of ovarian metastasis after gastric cancer surgery.Conclusion The increase of NLR and FIB in patients with gastric cancer before operation and the patients with diffuse-type gastric cancer may have ovarian metastasis earlier,and the postoperative Lauren typing and preoperative peripheral blood NLR may be the independent risk factors of ovarian metastasis in patients with gastric cancer.