尿毒清颗粒联合非布司他片治疗高血压肾病合并高尿酸血症的临床研究

Clinical Study on Niaoduqing Granules Combined with Febuxostat Tablets in Treatment of Hypertensive Nephropathy Complicated with Hyperuricemia

目的研究尿毒清颗粒联合非布司他片治疗高血压肾病合并高尿酸血症的临床疗效。方法选取2020年6月-2021年7月在我院诊治的90例高血压肾病合并高尿酸血症患者为研究对象,采用随机数字表法分为观察组、对照A组、对照B组,各30例。对照组A组采用尿毒清颗粒治疗,对照组B组采用非布司他片治疗,观察组采用尿毒清颗粒联合非布司他片治疗,比较三组治疗总有效率、血压(收缩压、舒张压)、内皮细胞功能指标[一氧化氮(NO)、内皮素-1(ET-1)]、血脂指标[低密度脂蛋白胆固醇(LDL-C)、甘油三脂(TG)、总胆固醇(TC)]、RAS活性相关指标[卧位血浆肾素活性(PRA),血管紧张素Ⅱ(AngⅡ)]、尿酸水平。结果观察组治疗总有效率高于对照A组、对照B组,差异有统计学意义(P<0.05);三组治疗后收缩压、舒张压低于治疗前,且观察组低于对照A组、对照B组,差异有统计学意义(P<0.05);三组治疗后NO高于治疗前、ET-1低于治疗前,且观察组NO低于对照A组、对照B组,ET-1高于对照A组、对照B组,差异有统计学意义(P<0.05);三组治疗后LDL-C、TG、TC低于治疗前,且观察组低于对照A组、对照B组,差异有统计学意义(P<0.05);三组治疗后卧位PRA、AngⅡ低于治疗前,且观察组低于对照A组、对照B组,差异有统计学意义(P<0.05);三组治疗后尿酸水平低于治疗前,且观察组低于对照A组、对照B组,差异有统计学意义(P<0.05)。结论尿毒清颗粒联合非布司他片治疗高血压肾病合并高尿酸血症疗效确切,可有效降低血压及血脂指标,改善血管内皮功能,降低RAS系统活性,具有应用有效性。

Objective To study the clinical efficacy of Niaoduqing Granules combined with Febuxostat Tablets in the treatment of hypertensive nephropathy with hyperuricemia.Methods A total of 90 patients with hypertensive nephropathy complicated with hyperuricemia who were treated in our hospital from June 2020 to July 2021 were selected as the research objects.They were randomly divided into observation group,control group A and control group B,with 30 cases in each group.The control group A was treated with Niaoduqing granules,the control group B was treated with febuxostat tablets,and the observation group was treated with Niaoduqing granules combined with febuxostat tablets.The total effective rate,blood pressure(systolic and diastolic blood pressure),endothelial cell function indexes[nitric oxide(NO),endothelin-1(ET-1)],blood lipid indexes[low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)],RAS activity related indexes[supine plasma renin activity(PRA),angiotensinⅡ(AngⅡ)]and uric acid levels were compared among the three groups.Results The total effective rate of the observation group was higher than that of the control group A and the control group B,and the difference was statistically significant(P<0.05).The systolic blood pressure and diastolic blood pressure of the three groups after treatment were lower than those before treatment,and the observation group was lower than the control group A and the control group B,the difference was statistically significant(P<0.05).NO in three groups after treatment was higher than before treatment,ET-1 was lower than before treatment,NO in observation group was lower than control group A and control group B,ET-1 was higher than control group A and control group B,the difference was statistically significant(P<0.05).LDL-C,TG and TC in the three groups after treatment were lower than those before treatment,and those in the observation group were lower than the control group A and the control group B,the difference was statistically significant(P<0.05).The PRA and AngⅡin the supine position of the three groups after treatment were lower than those before treatment,and the observation group was lower than the control group A and the control group B,the difference was statistically significant(P<0.05).The levels of uric acid in the three groups after treatment were lower than those before treatment,and the observation group was lower than the control group A and the control group B,the difference was statistically significant(P<0.05).Conclusion Niaoduqing granules combined with febuxostat tablets is effective in the treatment of hypertensive nephropathy with hyperuricemia,which can effectively reduce blood pressure and blood lipid indexes,improve vascular endothelial function,and reduce RAS system activity.