Paneth cell与肠道健康

Paneth cells and intestinal health

潘氏细胞(paneth cell,PC)是由肠道干细胞(intestinal stem cells,ISC)分化而来并定居于小肠隐窝底部的分泌性细胞,是肠道健康的重要“守卫者”.PC可分泌多种抗菌肽和细胞因子以调节肠道稳态与免疫反应,还可以合成分泌多种生长因子维持ISC的生态位,调控ISC增殖分化,甚至可作为静态干细胞库,在肠组织受损时获得干细胞样特性促进组织再生,从而有助于修复受损的肠组织.此外,PC与一些影响肠道健康的疾病密切相关,如炎症性肠病(inflammatory bowel disease,IBD)和结直肠癌(colorectal cancer,CRC),对于PC的研究或许可以为这些疾病的治疗提供思路.由此可见,PC功能的正常在维持肠道生理作用中值得高度重视.

Paneth cells(PC)are a group of secretory cells derived from intestinal stem cells(ISC)and colonized in the bottom of the small intestinal crypt.As an important“guardian”of intestinal health,PC can not only secrete a variety of antibacterial peptides and cytokines to regulate intestinal homeostasis and participate in immune responses,but also release growth factors to support the stem cell niche and regulate their proliferation and differentiation.Of particular concern,as a static stem cell pool,PC can acquire a stem cell-like transcriptome after the injury of intestinal tissue so as to promote regeneration and repair the damaged intestinal tissue.Particularly,PC are closely related to a number of diseases that affect intestinal health,such as inflammatory bowel disease(IBD)and colorectal cancer(CRC).The research of biological functions of PC may provide ideas for the treatment of these diseases.In summary,the role of PC in maintaining intestinal health should not be underestimated.