银离子敷料联合负压引流治疗感染性伤口的系统评价

Silver ion dressing combined with negative pressure drainage for the treatment of infectious wounds:a systematic review

目的探讨银离子敷料联合负压引流治疗感染性伤口的有效性。方法检索Cochrane Library、PubMed、Embase、Web of Science、中国生物医学文献服务系统、中国知网、万方数据平台、维普中文期刊服务平台等数据库中关于银离子敷料联合负压引流治疗感染性伤口的随机对照研究,由2名研究人员进行资料提取和文献质量评价,并使用RevMan 5.4软件进行Meta分析。结果共纳入9篇文献,总样本量为690例,其中试验组采用银离子敷料联合负压引流疗法,对照组采用银离子敷料、负压引流疗法或常规换药中一种方式进行治疗。Meta分析结果:试验组能降低压疮愈合计分量表评分[MD=-1.44,95%CI(-2.49,-0.39),Z=2.70,P=0.007]、细菌阳性率[OR=0.37,95%CI(0.27,0.50),Z=6.16,P<0.001],缩短伤口愈合时间[MD=-6.70,95%CI(-9.00,-4.40),Z=5.71,P<0.001],提高伤口痊愈率[OR=3.32,95%CI(1.72,6.40),Z=3.58,P<0.001]。结论银离子敷料联合负压引流治疗能有效促进感染性伤口的愈合。

Objective To investigate the effectiveness of silver ion dressing combined with negative pressure drainage in the treatment of infectious wounds.Methods A comprehensive literature search was conducted in the Cochrane Library,PubMed,Embase,Web of Science,SinoMed,CNKI,Wanfang Data Platform,VIP datebase and other databases for randomized controlled trials of silver ion dressing combined with negative pressure drainage to treat infectious wound.Two researchers conducted data extraction and quality evaluation,and used RevMan 5.4 software for meta-analysis.Results A total of 9 articles were included,with a sample size of 690.Patients in the experimental group were treated with silver ion dressing combined with negative pressure drainage therapy,and patients in the control group were treated with silver ion dressing,negative pressure drainage therapy or conventional dressing change.Meta analysis results showed that the silver ion dressing combined with negative pressure drainage therapy can reduce the Pressure Ulcer Scale for Healing score[MD=-1.44,95%CI(-2.49,-0.39),Z=2.70,P=0.007],positive rate of bacteria[OR=0.37,95%CI(0.27,0.50),Z=6.16,P<0.001],wound healing time[MD=-6.70,95%CI(-9.00,-4.40),Z=5.71,P<0.001],and improve the wound healing rate[OR=3.32,95%CI(1.72,6.40),Z=3.58,P<0.001].Conclusion Silver ion dressing combined with negative pressure drainage therapy can effectively promote the healing of infectious wounds.