经典名方厚朴温中汤的历史衍变与研究进展

Historical Evolution and Modern Research of Houpo Wenzhongtang

厚朴温中汤是《古代经典名方目录(第一批)》中收录方剂。笔者通过整理古代医籍、现代文献,系统考证厚朴温中汤处方来源、组方、主治等历史沿革及研究现状。发现该方最早见于金代名医李东垣所著《内外伤辨惑论》,主治脾胃虚寒,心腹胀满。后世医籍记载主治与原方基本一致;煮散剂与水煎剂的剂量不同但用药比例一致;清代时出现丸剂记载。现代主要用该经典名方治疗胃肠道疾病如胃痛、胃肠炎及功能性消化不良等;药理研究发现其具有抗炎、止痛、调节胃肠道功能等作用;药材粒度及煎煮水量对该方各指标性成分无明显影响。笔者通过全面文献考证,可为经典名方厚朴温中汤的现代开发提供理论依据与文献参考。

Houpo Wenzhongtang is listed in the Catalogue of Ancient Famous Classical Formulas First Batch),this paper systematically researched the historical evolution and research status of the origin,composition and indications of this formula by sorting out ancient medical books and modern literaturec.It wasfound that Houpo Wenzhongtang was first recorded in Neiwaishang Bianhuolun(《内外伤辨惑论》)written byLI Dong-yuan,a famous doctor in the Jin dynasty.This famous classical formula was used to treat deficiency andcold of spleen and stomach,and distention and fulness of heart and abdomen.The records of attending in thelater medical books were basically consistent with the original formula.The decoction pieces dosage of boiledpowder and water decoction was different,while the proportion of decoction pieces was the same.In the Qing dynasty,pills of Houpo Wenzhongtang was recorded.Houpo Wenzhongtang in modern clinical practice was used to treat gastrointestinal diseases such as stomachache,gastroenteritis and functional dyspepsia.Pharmacological studies have found that it has anti-inflammatory,analgesic,regulating gastrointestinal function and so on.The particle size and decocting water amount had no significant effect on the index components.In short,this paper can provide theoretical basis and literature reference for the development of this famous classical formula.