N6-甲基腺苷甲基化与肾脏缺血再灌注损伤关系的研究进展

Research progress on the relationship between N6-methyladenosine methylation and renal ischemia-reperfusion injury

缺血再灌注损伤(I/R损伤)是急性肾损伤(AKI)的重要原因,它是由短暂的血流减少或停止再灌注引起的。I/R损伤可导致急性细胞死亡、组织损伤,甚至永久性器官功能障碍。肾脏I/R损伤机制复杂多样,目前尚待深入的研究。RNA甲基化是一种新的表观遗传修饰,参与调控多种生物学过程,如免疫反应、肿瘤的发生转移、干细胞更新、脂肪分化、昼夜节律、细胞发育分化和细胞分裂等。N6-甲基腺苷(m6A)是真核生物最常见和最丰富的RNA分子修饰,m6A的研究已经证实它们参与了肾脏I/R损伤的调节。本文就m6A甲基化在肾脏I/R损伤中的调控作用和意义的研究进展作一综述。

Ischemia/reperfusion injury(I/R injury)is an important cause of(AKI)in acute renal injury,which is caused by transient decrease of blood flow or cessation of reperfusion.I/R injury can lead to acute cell death,tissue damage,and even permanent organ dysfunction.The mechanism of renal I/R injury is complex and diverse,which needs to be further studied at present.RNA methylation is a new epigenetic modification,which participates in the regulation of a variety of biological processes,such as immune response,tumor metastasis,stem cell renewal,adipose differentiation,circadian rhythm,cell development and differentiation,cell division and so on.N6-methyladenosine(m6A)is the most common and abundant RNA molecular modification in eukaryotes.m6A studies have confirmed that they are involved in the regulation of renal I/R injury.This article reviews the research progress on the regulatory role and significance of m6A methylation in renal I/R injury.