血管周围脂肪组织在腹主动脉瘤发生发展中的作用与机制研究进展

Research progress on the role and mechanism of perivascular adipose tissue in the occurrence and development of abdominal aortic aneurysms

血管周围脂肪组织(PVAT)分布在血管外膜周围,并与外膜直接接触。PVAT内含有多种细胞,可分泌多种细胞因子,对心血管疾病的进程具有重要意义。PVAT的功能障碍会影响腹主动脉瘤(AAA)的多种发病机制。本文将就PVAT简介、PVAT内主要细胞构成、PVAT与AAA发病相关机制展开综述。

Perivascular adipose tissue(PVAT)is directly distributed around vascular adventitia.In addition,PVAT contains a variety of cells which can secrete a variety of cytokines,thus playing an important role in the progression of cardiovascular disease.Dysfunction of PVAT affects multiple pathogenesis of abdominal aortic aneurysm(AAA).This articlewillreview the induction of PVAT,the maincell types in PVAT,the correlation between PVAT and the pathogenesis of AAA.