泛素特异性蛋白酶在肿瘤演进过程中的研究进展

Research progress of ubiquitin-specific peptidases in tumorigenesis and development

蛋白泛素化是生理条件下调控蛋白质稳定性和活性的重要机制之一, 其中E1/E2/E3连接酶和去泛素化酶在蛋白泛素化过程中发挥着重要调节作用, 而去泛素化则可能会诱导肿瘤、哮喘等疾病的发生。泛素特异性蛋白酶作为去泛素化酶家族中的主要成员被证实与肿瘤的发生、发展密切相关, 其中部分泛素特异性蛋白酶已经被用于抗肿瘤治疗的潜在靶点进行研究。因此, 本研究旨在通过对泛素特异性蛋白酶在肿瘤演进过程中的调控机制作一简要综述, 期望为肿瘤治疗提供更多的研究参考。

Protein ubiquitination is one of the important mechanisms regulating protein stability and activity under physiological condition.Among them,E1/E2/E3 ligases and deubiquitination enzyme play an important regulatory role in the process of protein ubiquitination,while deubiquitination may induce the occurrence of tumors,asthma and other diseases.Ubiquitin-specific peptidases,as the main members of the deubiquitination enzyme family,have been proved to be closely related to the occurrence and development of tumors,among which some ubiquitin-specific peptidases have been used as new targets for anti-tumor therapy.Therefore,this study aims to briefly review the regulatory mechanisms of ubiquitin-specific peptidases in the process of tumor genesis and development,which will provide more research directions for tumor therapy.