Irisin在炎症性肠病中的作用及机制研究进展

Progress in studies on the role and mechanism of Irisin in inflammatory bowel disease

炎症性肠病(inflammatory bowel diease, IBD)是一组病因尚未阐明的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis, UC)和克罗恩病(Crohn diease, CD)。Irisin是2012年新发现的一种肌肉因子,具有促进白色脂肪棕色化、调节能量代谢、改善胰岛素抵抗等作用,在细胞炎症、氧化应激、凋亡等过程中扮演着十分重要的角色,已逐渐成为代谢性疾病的标志物和药物治疗的新靶点。本文总结了Irisin在炎症性肠病中的作用之研究进展,以期为炎症性肠病患者的诊治提供帮助。

Inflammatory bowel disease(IBD),including ulcerative colitis(UC) and Crohn Diease(CD),is a group of chronic,nonspecific inflammatory bowel diseases whose etiology has not yet been clarified.Irisin is a muscle factor newly discovered in2012,which promotes the browning of white fat,regulates energy metabolism,and improves insulin resistance.It plays a very important role in cellular inflammation,oxidative stress,apoptosis and other processes.It has gradually become a marker of metabolic diseases and a new target for drug therapy.In the present study,we summarize the research progress of the role of Irisin in IBD in order to provide help for the diagnosis and treatment of the patients with IBD.