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结核分枝杆菌的耐药机制研究进展 被引量：12

Research progress on the drug resistance mechanism of Mycobacterium tuberculosis
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摘要 结核病是由结核分枝杆菌引起的一种人兽共患慢性传染病,随着结核分枝杆菌自身演变和抗结核病药物的使用,导致结核分枝杆菌产生耐药性。目前根据结核病患者是否接受过抗结核病药物的治疗,将结核分枝杆菌的耐药性分为两种,一种是原发性耐药,另一种是获得性耐药。为了探索结核分枝杆菌的耐药机制,本文对原发性与获得性耐药机制进行阐述,为后续新型抗结核病药物的研发奠定理论基础。 Tuberculosis is a serious zoonotic disease caused by Mycobacterium tuberculosis.With the evolution of M.tuberculosis and the use of anti-tuberculosis drugs,Mycobacterium tuberculosis has developed drug resistance.Depending on whether patients with TB have received anti-tuberculosis drug treatment,the drug resistance of Mycobacterium tuberculosis is mainly divided into two types,one is primary drug resistance and the other is acquired drug resistance.In order to explore the drug resistance mechanism of Mycobacterium tuberculosis,this article describes mechanisms of the primary and acquired drug resistance mechanisms in order to lay a theoretical foundation for the subsequent research and development of new anti-tuberculosis drugs.
作者 郑伟 田甜 王琦 刁乃超 李健明 时坤 杜锐 ZHENG Wei;TIAN Tian;WANG Qi;DIAO Nai-chao;LI Jian-ming;SHI Kun;DU Rui(College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China;College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China;Key Laboratory of Animal Production and Product Quality and Safety of the Ministry of Education,Changchun 130118,China;Jilin Province Sika Deer High-efficiency Breeding and Product Development Technology Engineering Research Center,Changchun 130118,China)
机构地区 吉林农业大学动物科学技术学院 吉林农业大中药材学院 动物生产及产品质量安全教育部重点实验室 吉林省梅花鹿高效养殖和产品开发技术工程研究中心
出处 《中国人兽共患病学报》 CAS CSCD 北大核心 2021年第11期1044-1052,共9页 Chinese Journal of Zoonoses
基金 国家重点研发计划资助项目(No.2018YFC1706604-03)。
关键词 结核分枝杆菌 原发性耐药 获得性耐药 Mycobacterium tuberculosis primary drug resistance acquired drug resistance
分类号 R378.91 [医药卫生—病原生物学]
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中国人兽共患病学报
2021年 第11期

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