胰腺神经内分泌肿瘤CT征象与SSTR2、VEGFR2及MGMT表达的关系

Relationship of CT signs and Expression of SSTR2,VEGFR2 and MGMT in Pancreatic Neuroendocrine Neoplasms

【目的】探讨胰腺神经内分泌肿瘤(pNENs)的CT征象与生长抑素2型受体(SSTR2)、血管内皮生长因子2型受体(VEGFR2)及O^(6)-甲基鸟嘌呤-DNA甲基转移酶(O^(6)-methylguanine-DNA-methyltransferse,MGMT)表达的关系。【方法】收集2010年1月至2020年11月本机构经术后病理证实为pNENs 86例,所有患者术前均行增强CT检查,术后行SSTR2、VEGFR2、MGMT免疫组化检查。回顾性分析pNENs的CT特征与SSTR2、VEGFR2及MGMT表达情况的相关性,采用独立样本t检验或非参数检验及ROC曲线进行分析。【结果】SSTR2(+)组及SSTR2(-)组在性别、边界的差异有统计学意义(P<0.05),VEGFR2(+)组及VEGFR2(-)组在性别、最大径线≥20 cm、边界、强化率(动脉期、静脉期)及CT值比率(静脉期)的差异有统计学意义(P<0.05),MGMT(+)组及MGMT(-)组在最大径线≥20 cm、最大径、边界、强化率(动脉期)及CT值比率(平扫、动脉期、静脉期)的差异有统计学意义(P<0.05)。CT征象评估SSTR2、VEGFR2及MGMT阳性表达的AUC分别为0.847、0.761和0.749,灵敏度分别为87.18%,76.67%和90.48%,特异度分别为87.50%,73.91%和57.14%。【结论】CT征象联合临床特征可以反映pNENs中SSTR2、VEG⁃FR2及MGMT的表达。

【Objective】To investigate the relationship between CT signs and expression of somatostatin receptor type 2(SSTR2),vascular endothelial growth factor receptor type 2(VEGFR2)and O^(6)-methylguanine-DNA-methyltransferse(MGMT)in pancreatic neuroendocrine neoplasms(pNENs).【Methods】The data of 86 pNENs patients confirmed by histopathology were retrospectively analyzed,including CT imaging and expression of SSTR2,VEGFR2 and MGMT.Their correlations were identified by independent-samples t test,non-parametric test and receiver operating characteristic(ROC)curves.【Results】Gender and tumor boundary were significantly different between SSTR2-positive and SSTR2-negative pNENs patients(P<0.05).Gender,maximum diameter≥20 cm,boundary,enhancement ratio(arterial and venous phase)and CT value ratio(venous phase)were significantly different between VEGFR2-positive and VEGFR2-negative pNENs patients(P<0.05).Maximum diameter,maximum diameter≥20 cm,enhancement ratio(arterial phase)and CT value ratio(plain,arterial and venous phase)were significantly different between MGMT-positive and MGMT-negative pNENs patients(P<0.05).The AUCs of CT signs assessing positive expression of SSTR2,VEGFR2 and MGMT were 0.847,0.761 and 0.749 respectively,with sensitivity of 87.18%,76.67%and 90.48%respectively,specificity of 87.50%,73.91%and 57.14%respectively.【Conclusions】CT features combined with clinical manifestations can reflect expression of SSTR2,VEGFR2 and MGMT in pNENs.