帕罗西汀联合右佐匹克隆治疗抑郁症合并睡眠障碍患者的临床效果以及对睡眠质量的影响

Clinical Effect of Paroxetine Combined with Dexzopiclone in the Treatment of Depressive Patients with Sleep Disorders and Its Influence on Sleep Quality

目的:观察帕罗西汀联合右佐匹克隆治疗抑郁症合并睡眠障碍患者的临床效果以及对睡眠质量的影响。方法:选取2018年5月至2019年12月天水市第三人民医院收治的抑郁症合并睡眠障碍患者120例作为研究对象,按照随机数字表法分为观察组和对照组,每组60例。对照组患者给予帕罗西汀治疗,观察组患者在对照组患者的基础上联合使用右佐匹克隆进行治疗,采用匹兹堡睡眠指数量表(Pittsburgh Sleep Quality Index,PSQI)观察2组患者睡眠质量的改善情况,同时采用汉密尔顿抑郁量表(Hamilton Depression Rating Scale;HAMD)比较2组患者治疗的总有效率。结果:1)2组患者睡眠质量比较:治疗后,观察组的睡眠质量明显优于对照组,2组比较差异有统计学意义(P<0.05);2)2组患者治疗总有效率比较:治疗后,观察组患者的治疗总有效率显著高于对照组,2组比较差异有统计学意义(P<0.05)。结论:采用帕罗西汀联合右佐匹克隆治疗抑郁症合并睡眠障碍患者效果显著,值得临床推广使用。

Objective:To observe the clinical effect of paroxetine combined with dexzopiclone in the treatment of depression patients with sleep disorders and its influence on sleep quality.Methods:A total of 120 patients with depression complicated with sleep disorder admitted to The Third People′s Hospital of Tianshui city from May 2018 to December 2019 were selected as the research objects,and they were divided into observation group and control group according to random number table method,with 60 cases in each group.Control group was treated with paroxetine,observation group was treated with dexzopicone on the basis of control group.After treatment,the changes of wake times,sleep latency,sleep time and other indicators between 2 groups were observed,and Hamilton Depression Rating Scale(HAMD)was used to compared the total effective rate of 2 groups.Results:1)Comparison of sleep quality between two groups:after treatment,the sleep quality of the observation group was significantly higher than that of the control group,with statistical significance(P<0.05);2)Comparison of total effective rate between 2 groups:After treatment,the total effective rate of observation group was significantly higher than that of control group,with statistical significance(P<0.05).Conclusion:Paroxetine combined with dexzopiclone in the treatment of depression patients with sleep disorders has a significant effect,which is worthy of clinical application.