复合维生素预防高危孕妇发生子痫前期的效果及对凝血功能与炎症因子的影响

Effect of multivitamins on prevention of preeclampsia in high risk pregnant women and its influence on coagulation function and inflammatory factors

目的:探究复合维生素预防高危孕妇发生子痫前期(PE)的效果及对凝血功能与炎症因子的影响。方法:选取106例具PE高危因素的孕妇为研究对象,按干预因素不同分为对照组和观察组,每组各53例。对照组予以常规妊娠期保健;观察组在对照组基础上增加复合维生素治疗,疗程均为3个月。比较两组孕妇PE发生情况、妊娠结局及干预前后血压[收缩压(SBP)/舒张压(DBP)]、凝血功能[血小板计数(PLT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)]、炎症因子[白细胞介素6(IL-6)、IL-12、肿瘤坏死因子α(TNF-α)]水平。结果:两组孕妇PE发病孕周比较,差异无统计学意义(P>0.05)。观察组PE发生率、早产发生率、围产儿不良结局总发生率均低于对照组(P<0.05)。干预后,观察组SBP、DBP、FIB、D-D、IL-6、IL-12、TNF-α水平低于对照组(P<0.05),PLT、APTT高于对照组(P<0.05)。结论:高危孕妇在妊娠期服用复合维生素可有效预防PE发生,可能与其降低孕妇血压、改善凝血功能、减轻炎症有关。

Objective:To explore the effect of multivitamin on prevention of preeclampsia(PE)in high-risk pregnant women and its influence on coagulation function and inflammatory factors.Methods:106 pregnant women with PE risk factors were selected as the research object.They were divided into control group and observation group according to different intervention factors,with 53 cases in each group.The control group was given routine health care during pregnancy,the observation group was given compound vitamin treatment on the basis of the control group,and the course of treatment was 3 months.The incidence of PE,pregnancy outcome,blood pressure(DBP/SBP),coagulation function(PLT,APTT,FIB,D-D),inflammatory factors[Interleukin 6(IL-6),IL-12,tumor necrosis factorα(TNF-α)]before and after intervention were compared between the two groups.Results:There was no significant difference in gestational age of PE between the two groups(P>0.05).The incidence of PE,premature delivery and the total incidence of perinatal adverse outcomes in the observation group were significantly lower than those in the control group(P<0.05).After intervention,the levels of SBP,DBP,FIB,D-D,IL-6,IL-12 and TNF-αin the observation group were lower than those in the control group(P<0.05),and PLT and APTT were higher in the observation group than those in the control group(P<0.05).Conclusion:High risk pregnant women taking multivitamins during pregnancy can effectively prevent PE,reduce maternal blood pressure,improve coagulation function,reduce inflammation may be its mechanism of action.