摘要
The outbreak of coronavirus disease 2019(COVID-19)is a significant challenge for clinicians,especially for immunocompromised cancer patients.By analyzing the impact of COVID-19 on the immune microenvironment of colorectal cancer(CRC)patients at the tissue level and single-cell level,we found that CRC patients are more easily infected by severe acute respiratory syndrome coronavirus-2(SARSCoV-2),but promotion of infiltration and differentiation of monocytes makes them more likely to develop severe COVID-19.Because of the continuing activation of nuclear factor(NF)-κB and C-C chemokine receptor type 5(CCR5)signaling pathways in monocytes,imbalance of macrophage polarization can aggravate the cytokine release syndrome.Therefore,regulating the infiltration and differentiation of monocytes is helpful for the treatment of COVID-19 in CRC patients.
基金
the National Key Research and Development Program of New Coronary Pneumonia and Other Infectious Diseases Prevention Basic Research Orientation Project of China,No.2020YFA0707704(to Qian L)
the Ministry of Science and Technology of the People’s Republic of China,No.2016YFC1303800(to Cui JW)
the Interdisciplinary Research Funding Program of Jilin University,No.101832020DJX083(to Bai L)
and the Outstanding Talent Cultivation Program for Doctoral Students in Norman Bethune Health Science Center of Jilin University(to Bai L).
