羊膜衍生物移植治疗糖尿病足的研究进展

Research progress in amniotic membrane transplantation for diabetic foot management

评价羊膜组织促糖尿病足溃疡愈合的效果,并探讨其机制,为糖尿病足的治疗提供新思路。以生物敷料、糖尿病足等为检索词,检索CNKI、PubMed等数据库,筛选多中心、随机对照试验等高质量文献。对其结果分析、归纳、汇总做出结论。羊膜组织及其衍生物可显著缩短溃疡面愈合时间,这与其促血管组织再生、抗感染、促神经修复等有关,且新的衍生物将更加方便使用,为糖尿病足的治疗提供新工具。

The purpose of this review is to evaluate the promoting effects of amniotic membrane tissue on ulcer healing and investigate the underlying mechanism,providing new ideas for diabetic foot management.A computer-based online search of CNKI,PubMed and other databases to screen multi-center,randomized controlled trials published in high-impact journals using biological dressings,diabetic foot and other search terms.The retrieved data were analyzed and summarized.Amniotic membrane tissue and its derivatives can greatly shorten the time taken for healing of ulcer surface.This occurs possibly because they can promote angiogenesis and neural repair and prevent against infection.Moreover,the new derivatives provide great ease in use.Therefore,amniotic membrane and its derivatives provide a new tool for diabetic foot management.