重视自身抗体的精准定量检测

Value precision quantification of autoantibody assay

自身抗体在自身免疫性疾病的诊断、活动性判断及疗效监测中起重要作用。多种自身抗体联合检测是当前的主流检测方式,但通常只能报告定性或半定量结果,而新近发布的自身免疫性疾病的诊断/分类标准要求对自身抗体进行定量检测,且自身抗体的水平越高,诊断为自身免疫性疾病的可能性越大,与自身免疫性疾病的活动度可能更相关。本文就自身抗体精准定量检测的临床价值、检测现状与挑战作一介绍。

Autoantibodies play an important role in aiding to the diagnosis,as well as judging diseases activity and monitoring treatment of autoimmune disorders.The combined detection of multiple autoantibodies is the current mainstream detection method.However,results are frequently reported as qualitative or semi-quantitative.The newly released diagnostic/classification standards for autoimmune diseases require quantitative detection data about the level of autoantibodies.The higher the level of autoantibodies is,the more likely the patient is to be diagnosed as an autoimmune disease,and it may be more relevant to the activity of the autoimmune disease.This article makes an introduction about the clinical value of accurate quantitative detection of autoantibodies as well as the current statues and challenges at the moment.