惠普尔养障体导致急性肺炎的探讨

Tropheryma whipplei as the cause of acute pneumonia

惠普尔养障体(TW)是一种条件致病菌,可以引起一种少见疾病——Whipple病(WD)。TW是否可以引起肺炎,目前引起了业界的关注和讨论。支气管肺泡灌洗液(BALF)用聚合酶链反应(PCR)检测时,TW阳性率约为6.1%;其致病性一般描述为“相关”或“极似(probable)”,免疫受损时易感,有同一属不同菌种的报道,目前方法可能有漏检,所有相关信息均需要进一步研究。对没有WD胃肠道表现且肠道活检TW阴性,急性肺部感染临床诊断成立,BALF或肺组织有TW检出的患者,按照免疫正常或受损、TW单一或混杂、浓度或序列数高或低等,分别给出了诊疗建议。

Tropheryma whipplei(TW)is an opportunistic pathogen that can cause Whipple′s disease(WD).Recently,the biomedical field is concerned about whether the bacteria cause pneumonia.When BALF was detected by PCR,the TW positive rate was about 6.1%.Etiology status is generally described as“associated”or“probable”.Immunocompromised status is the susceptible factor;Different species of the same genus have been reported.The current method may have missed detection.All relevant information needs further study.This article reviews the acute pneumonia caused by TW and the detection technology.