两地汤加味联合地屈孕酮治疗先兆流产阴虚血热证疗效研究

Study on Curative Effect of Modified Liangdi Tang Combined with Dydrogesterone for Threatened Abortion with Yin Deficiency and Blood Heat Syndrome

目的:观察两地汤加味联合地屈孕酮治疗先兆流产阴虚血热证的疗效。方法:选取68例先兆流产患者,按随机数字表法分为2组各34例。对照组给予地屈孕酮片治疗,观察组予两地汤加味联合地屈孕酮片治疗,2组均连续治疗2周。比较2组患者的症状体征消失时间、临床疗效,观察治疗前后2组患者阴虚血热证症状以及血清激素水平的变化。结果:治疗2周后,观察组临床疗效总有效率为97.06%,对照组为76.47%,2组总有效率比较,差异有统计学意义(P<0.05)。观察组腹痛、腰痛、宫缩、阴道出血消失时间均较对照组缩短(P<0.01)。2组腰腹坠胀作痛、五心烦热、口干咽燥、小便短黄、大便秘结评分均较治疗前减少(P<0.01),观察组上述症状评分均低于对照组(P<0.01)。2组血清雌二醇(E2)、孕酮(P)、人绒毛膜促性腺激素(HCG)水平均较治疗前升高(P<0.01),观察组血清E2、P、HCG水平均高于对照组(P<0.01)。结论:两地汤加味联合地屈孕酮片治疗先兆流产阴虚血热证疗效显著,有助于促进症状体征的缓解,并能有效改善患者体内的激素水平。

Objective:To observe the curative effect of modified Liangdi tang combined with dydrogesterone for threatened abortion with yin deficiency and blood heat syndrome.Methods:A total of 68 cases of patients with threatened abortion were selected and divided into two groups according to random number table method,34 cases in each group.The control was given dydrogesterone tablets,and the observation group was given modified Liangdi tang combined with dydrogesterone.Both groups were continuously treated for two weeks.The disappearance time of symptoms and signs and clinical effect were compared between the two groups.Before treatment and after two-week treatment,symptoms of yin deficiency and blood heat syndrome and changes in levels of serum hormones were observed in the two groups.Results:After two-week treatment,the total effective rate was 97.06%in the observation group,and 76.47%in the control group,the difference being significant(P<0.05).The disappearance time of abdominal pain,low back pain,uterine contraction,and vaginal bleeding in the observation group was earlier than that in the control group(P<0.01).Scores of bearing-down and distending pain of low back and abdomen,scores of vexing heat in the chest,palms and soles,scores of dry mouth and throat,scores of scanty yellowish urine,and scores of hard bound stool in the two groups were decreased when compared with those before treatment(P<0.01),and the scores in the observation group were all lower than those in the control group(P<0.01).Levels of estradiol(E2),progesterone(P),and human chorionic gonadotropin(HCG)in serum in the two groups were increased when compared with those before treatment(P<0.01),and the three levels in the observation group were higher than those in the control group(P<0.01).Conclusion:The therapy of modified Liangdi tang combined with dydrogesterone tablets has a significant curative effect in the treatment of threatened abortion with yin deficiency and blood heat syndrome.It can help promote the relief of symptoms and signs and effectively improve the hormone levels of patients.