醒脑静注射液对急性高血压性脑出血患者神经功能的影响及抗炎作用研究

Study of Effect of Xingnaojing Injection on Neurological Function and Anti-Inflammation in Patients with Acute Hypertensive Cerebral Hemorrhage

目的:观察醒脑静注射液对急性高血压性脑出血患者神经功能的影响及其抗炎效果。方法:选择急性高血压性脑出血患者80例为研究对象,按随机数字表法分为对照组和观察组各40例。对照组给予控制血压、预防感染、脱水等常规治疗,观察组在常规治疗的基础上加用醒脑静注射液治疗。观察比较2组治疗前及治疗后1、5、10、14 d神经功能缺损评分,比较2组治疗前后血清纤维蛋白原(Fib)、神经元特异性烯醇化酶(NSE)和基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)水平变化。结果:治疗前及治疗1 d,2组神经功能缺损评分比较,差异无统计学意义(P>0.05);治疗5、10、14 d,观察组神经功能缺损评分明显低于对照组,差异有统计学意义(P<0.05)。治疗前,2组生化功能指标Fib、NSE、MMP-9水平比较,差异无统计学意义(P>0.05);治疗后,2组Fib水平较治疗前升高,NSE、MMP-9水平较治疗前降低(P<0.05),且观察组各项指标改善较对照组更显著(P<0.05)。治疗前,2组炎性因子TNF-α、hs-CRP、PCT比较,差异无统计学意义(P>0.05)。治疗后,2组TNF-α、hs-CRP、PCT水平均较治疗前降低(P<0.05),且观察组各项指标低于对照组(P<0.05)。结论:醒脑静注射液治疗急性高血压性脑出血疗效显著,可通过上调血清Fib水平,抑制NSE、MMP-9的生成,改善患者神经功能,同时可通过抑制炎症反应,避免病情加重。

Objective: To observe the effect of Xingnaojing injection on neurological function and anti-inflammation in patients with acute hypertensive cerebral hemorrhage. Methods: A total of 80 cases of patients with acute hypertensive cerebral hemorrhage were selected as the study subjects, and divided into the control group and the observation group according to the random number table method,with 40 cases in each group. The control group was given routine treatment including controlling blood pressure, preventing infection and dehydrating, and the observation group was additionally treated with Xingnaojing injection based on the routine treatment. Before treatment and after 1, 5, 10 and 14 days of treatment,the scores of National Institute of Health Stroke Scale in the two groups were observed and compared. Before and after treatment,the changes in levels of plasma fibrinogen(Fib),neuron-specific enolase(NSE),matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP) and procalcitonin(PCT) in the two groups were compared. Results:Before treatment and after one-day treatment,there was no significant difference being found in the comparison of the scores of National Institute of Health Stroke Scale between the two groups(P>0.05). After 5,10 and 14 days of treatment, the scores of National Institute of Health Stroke Scale in the observation group were significantly lower than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the biochemical function indexes including Fib, NSE and MMP-9 between the two groups(P>0.05). After treatment,the Fib levels in the two groups were increased when compared with those before treatment,and the levels of NSE and MMP-9 were decreased(P<0.05),and the improvement of the indexes in the observation group was more significant than that in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of the inflammatory factors including TNF-α,hs-CRP and PCT between the two groups(P>0.05). After treatment,the levels of TNF-α,hs-CRP and PCT in the two groups were decreased when compared with those before treatment(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05). Conclusion: Xingnaojing injection has a significant curative effect in treating acute hypertensive cerebral hemorrhage,and can play a therapeutic role by increasing the content of Fib in serum and inhibiting the production of NSE and MMP-9, so as to improve the neurological function of patients, and at the same time avoid the aggravation of the disease by inhibiting the inflammatory reactions.