清肝利胆方联合熊去氧胆酸片治疗慢性胆囊炎临床研究

Clinical Study on Qinggan Lidan Prescription Combined with Ursodeoxycholic Acid Tablets for Chronic Cholecystitis

目的:观察清肝利胆方联合熊去氧胆酸片治疗慢性胆囊炎的临床疗效。方法:选取92例慢性胆囊炎患者,按病历编号单双数分为对照组和观察组各46例。对照组给予熊去氧胆酸片治疗,观察组在对照组基础上加用清肝利胆方治疗,2组均治疗4周。比较2组临床疗效及不良反应;比较2组治疗前后胆囊壁厚度、胆囊体积及总胆汁酸(TBA)、总胆固醇(TC)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平。结果:观察组总有效率为93.48%,高于对照组的78.26%(P<0.05)。治疗后,2组胆囊壁厚度、胆囊体积均较治疗前缩小(P<0.05),观察组胆囊壁厚度、胆囊体积均小于对照组(P<0.05);2组TBA、TC、IL-1β、TNF-α水平均较治疗前降低(P<0.05),观察组TBA、TC、IL-1β、TNF-α水平均低于对照组(P<0.05)。治疗过程中,2组均未出现严重不良反应。结论:清肝利胆方联合熊去氧胆酸片治疗慢性胆囊炎可提高临床疗效,促进胆囊功能恢复,减轻炎症反应。

Objective:To observe the clinical effect of Qinggan Lidan prescription combined with ursodeoxycholic acid tablets for chronic cholecystitis.Methods:A total of 92 cases of patients with chronic cholecystitis were divided into the control group and the observation group according to the number of the cases by the single-double method,with 46 cases in each group.The control group was treated with ursodeoxycholic acid tablets,and the observation group was additionally treated with Qinggan Lidan prescription based on the treatment of the control group.Both groups were treated for four weeks.The thickness of gallbladder wall,gallbladder volume,and levels of total bile acid(TBA),total cholesterol(TC),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)before and after treatment as well as the clinical effects and adverse reactions in the two groups were compared.Results:The total effective rate was 93.48%in the observation group,higher than that of 78.26%in the control group(P<0.05).After treatment,the thickness of gallbladder wall and gallbladder volume in the two groups were decreased when compared with those before treatment(P<0.05),and the thickness of gallbladder wall and gallbladder volume in the observation group were smaller than those in the control group(P<0.05);the levels of TBA,TC,IL-1βand TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the levels of TBA,TC,IL-1βand TNF-αin the observation group were lower than those in the control group(P<0.05).During treatment,there was no serious adverse reactions in the two groups.Conclusion:Qinggan Lidan prescription combined with ursodeoxycholic acid tablets for chronic cholecystitis can improve clinical effect,promote the recovery of gallbladder function,and relieve inflammatory responses.