白藜芦醇对酒精性肝病保护作用机制的研究进展

Research progress on the protective mechanism of resveratrol on alcoholic liver disease

有200多种疾病的病因与酗酒有关,酒精会造成全身各系统的疾病。作为酒精吸收和代谢的场所,过量饮酒导致的胃肠道和肝脏损害不容忽视。酒精会产生较强的肝脏毒性,造成肠道微生物的紊乱。白藜芦醇是一种广泛存在于葡萄、花生、坚果等各种食物中的天然多酚,具有保护肝脏等多种益于人体健康的功能。本文回顾白藜芦醇对酒精性肝病保护作用的相关机制,提出了肠道微生物可以作为白藜芦醇预防酒精性肝病的潜在研究靶点。

The causes of more than 200 diseases are related to alcoholism,which can cause disea-ses in all systems of the body.As the place of alcohol absorption and metabolism,the damage of gastrointes-tinal tract and liver caused by excessive drinking can not be ignored.Alcohol can produce strong hepatotox-icity,resulting in intestinal microbial disorders.Resveratrol is a kind of natural polyphenols which widely exist in grapes,peanuts,nuts and other foods.It has many functions that are beneficial to human health,such as liver protection.Therefore,we reviewed the mechanism of the protective effect of resveratrol on al-coholie liver disease and proposed that intestinal microorganisms could be a potential research target for res-veratrol in the prevention of alcoholic liver disease.