头颈部癌放疗联合免疫治疗研究进展

Progress of radiotherapy combined with immunotherapy for head and neck cancer

随着免疫治疗成为复发或转移性头颈部鳞状细胞癌(HNSCC)的最新疗法, 放疗联合免疫治疗也成为该领域的焦点, 已有研究表明二者联合可产生协同作用, 但其联合增效机制目前未有定论。基础研究涉及免疫细胞和微环境免疫调节, 临床研究包括联合治疗时机、放疗部位、治疗模式与剂量及受益人群的选择。文章主要阐述了放疗与免疫治疗联合应用在头颈部癌基础与临床治疗方面的研究进展。

As immunotherapy has become the latest treatment for recurrent or metastatic squamous cell carcinoma of the head and neck(HNSCC),radiotherapy combined with immunotherapy has become the focus of this field.It has been reported that radiotherapy combined with immunotherapy can produce synergistic effect,but the mechanism of synergistic effect has not been determined yet.Basic researches involve immune cells and immunoregulation of microenvironment,and clinical researches include timing of combination therapy,radiotherapy site,treatment mode and dose,and selection of beneficiary population.This paper reviews the progress of combined application of radiotherapy and immunotherapy in the field of basic and clinical treatment of head and neck cancer.