非编码RNA在骨肉瘤血管新生中的研究进展

Progress of non⁃coding RNA in angiogenesis of osteosarcoma

骨肉瘤在发展的过程中需不断诱导血管新生来满足自身营养的供给,因此对骨肉瘤细胞诱导的血管新生为靶点进行抑制,已成为近年来研究的热点。尽管目前针对mRNA编码蛋白为靶点的血管抑制剂已运用于临床,但效果欠佳。而非编码RNA(ncRNA)是一类不参与蛋白编码的RNA分子,可以通过调节血管内皮生长因子、血管生成素2和缺氧诱导因子-1等血管相关因子的分泌或ncRNA间的相互作用,进而调控骨肉瘤的血管新生。文章综述ncRNA在骨肉瘤血管新生中的作用,为临床上骨肉瘤靶向治疗策略提供参考。

Osteosarcoma needs to continuously induce angiogenesis to satisfy its own nutritional supply in the process of development.Therefore,the inhibition of osteosarcoma cell-induced angiogenesis as a target has become a research hot in recent years.Currently,vascular inhibitors targeting mRNA-encoded protein have been applied in clinic,but the efficacy is poor.Non-coding RNA(ncRNA)is a type of RNA molecules that do not participate in protein coding.ncRNA can regulate the angiogenesis of osteosarcoma by regulating the secretion of vascular factors such as vascular endothelial growth factor,angiogenin-2 and hypoxia-inducible factor 1 or the interaction between ncRNAs.This article reviews the role of ncRNA in the angiogenesis of osteosarcoma to provide references for clinical targeted therapy strategies for osteosarcoma.