芳香精油对维持性血液透析患者疲乏影响效果的Meta分析

The effect of aromatherapy on fatigue of maintenance hemodialysis patients:a Meta-analysis

目的评价芳香疗法对维持性血液透析患者疲乏的影响。方法检索国内外相关数据库从建库至2020年9月1日纳入的维持性血液透析患者采用芳香疗法缓解疲乏的随机对照试验文献6篇,共计435例患者,其中试验组213例,对照组222例。采用StataMP 16.0软件进行Meta分析。结果Meta分析结果显示标准化均数差(SMD)值为-0.94,95%可信区间(95%CI)-1.71~-0.18,2组合并效应量比较差异有统计学意义(Z值为2.42,P<0.05);以精油品种为指标进行亚组分析结果显示,薰衣草和柑橘精油混合组SMD值为-1.89,95%CI-3.22~-0.57,合并效应量有统计学意义(Z值为2.80,P<0.05);以精油计量为指标进行亚组分析结果显示,2滴组SMD值为-1.65,95%CI-2.65~-0.65,合并效应量有统计学意义(Z值为3.23,P<0.05);以干预时间为指标进行亚组分析结果显示,8周组SMD值为-1.23,95%CI-1.77~-0.70,合并效应量有统计学意义(Z值为4.51,P<0.05)。结论芳香疗法能够有效降低维持性血液透析患者的疲乏水平,且芳香疗法对疲乏的积极作用与精油的种类、剂量、干预时间密切相关。

Objective To evaluate the effect of aromatherapy on fatigue in maintenance hemodialysis patients.Methods Searching related domestic and foreign databases from the establishment of the database to September 1st,2020,included 6 randomized controlled trials of maintenance hemodialysis patients using aromatherapy to relieve fatigue,a total of 435 patients,including 213 in the experimental group and 222 in the control group example.StataMP 16.0 software was used for Meta-analysis.Results The result of Meta-analysis was SMD=-0.94,95%CI-1.71,-0.18,and the combined effect size of the two groups was compared,and the difference was statistically significant(Z value was 2.42,P<0.05).Subgroup analysis using essential oil varieties as indicators showed that the lavender and citrus essential oil mixed group SMD=-1.89,95%CI-3.22,-0.57,the combined effect size was statistically significant(Z value was 2.80,P<0.05);The results of subgroup analysis using essential oil measurement as an indicator showed that the 2-drop group SMD=1.65,95%CI-2.65,-0.65,and the combined effect size was statistically significant(Z value was 3.23,P<0.05);The results of subgroup analysis using intervention time as an indicator showed that the 8-week group SMD=-1.23,95%CI-1.77,-0.70,and the combined effect size was statistically significant(Z value was 4.51,P<0.05).Conclusions Aromatherapy can effectively reduce the fatigue level of maintenance hemodialysis patients,and the positive effect of aromatherapy on fatigue is closely related to the type,dosage and intervention time of essential oils.