牙周炎与炎症性肠病相关性研究的Meta分析

Association between periodontitis and inflammatory bowel diseases:A Meta-analysis

目的探究牙周炎与炎症性肠病之间的相关性。方法电子检索Medline、Pubmed、EMBASE、CBM、CNKI和维普等中英文期刊数据库并手工检索相关期刊,收集有关牙周炎与炎症性肠病相关性研究的文献。通过文献筛选和数据提取后采用Revman5.3.3进行Meta分析。结果最终纳入9篇英文文献,纳入研究对象35129名,其中炎症性肠病患者7676名。Meta分析结果显示炎症性肠病(OR=1.66,Z=13.21,P<0.00001),克罗恩病(OR=1.60,Z=11.92,P<0.00001)和溃疡性结肠炎(OR=3.33,Z=7.58,P<0.00001)患者的牙周炎患病率均明显高于对照组。结论牙周炎与克罗恩病和溃疡性结肠炎等炎症性肠病之间具有显著的相关性。

Objective To explore the association between periodontitis and inflammatory bowel diseases.Methods Chinese and English journal databases such as Medline,Pubmed,EMBASE,CBM,CNKI and VIP were searched electronically and examined by hand.The literatures on the association between periodontitis and inflammatory bowel diseases were collected through systematic literature screening and data extraction.Meta-analysis was performed by Revman 5.3.3.Results Nine English trials met the inclusion criteria,including 35129 participants,7676 of whom with inflammatory bowel diseases.The result of Meta-analysis showed that patients with inflammatory bowel diseases(OR=1.66,Z=13.21,P<0.00001),Crohn’s disease(OR=1.60,Z=11.92,P<0.00001)or ulcerative colitis(OR=3.33,Z=7.58,P<0.00001)were more likely to develop chronic periodontitis.Conclusion There is a significant correlation between periodontitis and inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.