NCAM1与口腔扁平苔藓的相关性研究进展

Research progress of the correlation between NCAM1 and oral lichen planus

神经细胞粘附分子1(neural cell adhesion molecule l,NCAM1)是一种非钙依赖性粘附分子,能介导细胞与细胞、细胞与细胞外基质间的相互作用。在神经系统的发育、免疫细胞功能的调节、细胞的识别及转移、肿瘤的浸润与生长等方面发挥重要作用。近年来的研究表明NCAM1可能参与了口腔扁平苔藓(oral lichen planus,OLP)的发生、发展及癌变过程。本文将从NCAM1的结构、功能及调节,NCAM1在OLP中的异常表达,NCAM1在OLP发生、发展中的可能作用及NCAM1与OLP癌变等方面作一综述。

Neural cell adhesion molecule l(NCAM1) is a calcium independent intercellular adhesion molecule, which can mediate the interaction of cell-to-cell and cell-to-matrix. Moreover, it plays an important role in the development of nervous system, the regulation of immune cell function, the recognition and metastasis of cells, and the invasion and growth of tumor. In recent years, studies have shown that NCAM1 may have being involved in the pathogenesis and cancerization of oral lichen planus(OLP).This article will review the research progress on NCAM1 in the following aspects:the structure, function, and regulation of NCAM1, the abnormal expression of NCAM1 in OLP, the possible role of NCAM1 in the occurrence and development of OLP, and NCAM1 and cancerization of OLP.