外泌体调控口腔鳞状细胞癌发生发展

Exosomes regulate the occurrence and development of oral squamous cell carcinoma

外泌体是小的膜状囊泡,含有来自亲代细胞大量的蛋白质、脂质、遗传物质及代谢物等,可以通过传递生物活性成分实现细胞间通信和信号传导,从而调控受体细胞的功能。口腔鳞状细胞癌(oral squamous carcinoma cancer, OSCC)是口腔颌面部最常见的恶性肿瘤。目前的研究证实,外泌体参与了OSCC发生、发展、侵袭、转移及化学耐药等多个方面,并且在OSCC的诊断、治疗、预后评价等方面发挥着重要作用。因此,了解外泌体在OSCC中促进癌症发生发展及转移的内在机制对于改善该疾病的治疗效果以及提高生存率显得尤为重要,本文就目前关于外泌体在促进OSCC发生发展、侵袭转移及化疗耐药中的研究进展作一综述。

Exosomes are small membranous vesicles that contain large amounts of proteins, lipids, genetic materials and metabolites from parent cells. They can transmit biologically active ingredients to achieve cell-to-cell communication and signal transduction, thereby regulating the function of recipient cells. Oral squamous carcinoma cancer(OSCC) is the most common malignant tumor in the oral and maxillofacial region. Current studies have confirmed that exosomes are involved in the occurrence, development, invasion, metastasis, and chemical resistance of OSCC, and play an important role in the diagnosis, treatment, and prognosis evaluation of OSCC.Therefore, understanding the internal mechanism of exosomes promoting the occurrence, development and metastasis of cancer in OSCC is particularly important for improving the treatment effect of the disease and increasing survival rate. This article reviews the research progress of the role of exosomes in promoting the occurrence, development, invasion, metastasis and chemotherapy resistance of OSCC.